Reactome | keratinocyte stem cell of skin epidermis basal layer

keratinocyte stem cell of skin epidermis basal layer

Stable Identifier

R-HSA-9725559

Type

Cell

Species

Homo sapiens

Synonyms

keratinocyte stem cell of skin epidermis stratum basale

Locations in the PathwayBrowser

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Cytology

Organ

skin of body (UBERON:0002097)

Tissue

skin epidermis (UBERON:0001003)

Tissue Layer

stratum basale of epidermis (UBERON:0002025)

Cell Type

stem cell of epidermis (CL:1000428)

Markers

Protein

CSPG4 [plasma membrane] (Homo sapiens)

- Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis.Development130,6049-63(2003)Leigh, I., Broad, S., Legg, J., Watt, FM., Jensen, UB.

LRIG1 [plasma membrane] (Homo sapiens)

- Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.Proc Natl Acad Sci U S A103,11958-63(2006)Watt, FM., Jensen, KB.

DLL1 [plasma membrane] (Homo sapiens)

- Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment.Stem Cell Reports18,2047-2055(2023)Philippeos, C., Haniffa, M., Watt, FM., Ganier, C., Louis, B., Ali, S., Reynolds, G., Zijl, S., Negri, VA.
- Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.Curr Biol10,491-500(2000)Le Roux, I., Lowell, S., Dunne, J., Watt, FM., Jones, P.
- Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.Proc Natl Acad Sci U S A103,11958-63(2006)Watt, FM., Jensen, KB.

ITGA6(24-1130) [plasma membrane] (Homo sapiens)

- CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Resnull,null(2022)Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
- Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment.Stem Cell Reports18,2047-2055(2023)Philippeos, C., Haniffa, M., Watt, FM., Ganier, C., Louis, B., Ali, S., Reynolds, G., Zijl, S., Negri, VA.
- Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype.Proc Natl Acad Sci U S A95,3902-7(1998)Simmons, PJ., Li, A., Kaur, P.

KRT19 [cytosol] (Homo sapiens)

- The type I keratin 19 possesses distinct and context-dependent assembly properties.J Biol Chem273,35176-84(1998)Fradette, J., Seshaiah, P., Germain, L., Coulombe, PA.
- CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Resnull,null(2022)Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
- [Epidermal growth factor induce the epithelial stem cell island formation in the regenerated epidermis].Zhonghua Yi Xue Za Zhi81,733-6(2001)Sun, T., Fu, X., Sun, X.

HC-ABCG2 [plasma membrane] (Homo sapiens)

- ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing.Exp Dermatol25,355-61(2016)Mao, WY., Huang, WC., Shen, CR., Shen, CN., Chang, HM., Lin, SJ., Huang, WY.
- CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Resnull,null(2022)Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
- Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis.Stem Cell Res Ther6,43(2015)Chua, AW., Ma, D., Lee, ST., Song, C., Teo, P., Yang, E., Lane, EB., Ting, Y.

ITGB4 [plasma membrane] (Homo sapiens)

- Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.Proc Natl Acad Sci U S A103,11958-63(2006)Watt, FM., Jensen, KB.
- Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function.Mol Biol Cell18,4210-21(2007)Janssen, H., Song, JY., Kreft, M., Sonnenberg, A., Raymond, K.

YAP1 [nucleoplasm] (Homo sapiens)

- Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin.Proc Natl Acad Sci U S A108,2270-5(2011)Fuchs, E., Pasolli, HA., Zhang, H.
- CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Resnull,null(2022)Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
- Yap1 acts downstream of α-catenin to control epidermal proliferation.Cell144,782-95(2011)Camargo, FD., Mohseni, M., Vasioukhin, V., Brummelkamp, TR., Kreger, BT., Avruch, J., Rodriguez, JR., Zhou, D., Pruszak, J., Schlegelmilch, K., Kirak, O.
- Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis.J Invest Dermatol133,1497-505(2013)Beverdam, A., Harvey, KF., Claxton, C., James, G., Key, B., Zhang, X.

ITGB1 [plasma membrane] (Homo sapiens)

- CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Resnull,null(2022)Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
- Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment.Stem Cell Reports18,2047-2055(2023)Philippeos, C., Haniffa, M., Watt, FM., Ganier, C., Louis, B., Ali, S., Reynolds, G., Zijl, S., Negri, VA.
- Enrichment and identification of human 'fetal' epidermal stem cells.Hum Reprod19,968-74(2004)Cao, YJ., Chen, SY., Duan, EK., Zhou, JX., Liu, WM.
- Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis.Development130,6049-63(2003)Leigh, I., Broad, S., Legg, J., Watt, FM., Jensen, UB.
- [Epidermal growth factor induce the epithelial stem cell island formation in the regenerated epidermis].Zhonghua Yi Xue Za Zhi81,733-6(2001)Sun, T., Fu, X., Sun, X.

TP63 [nucleoplasm] (Homo sapiens)

- p63 expression in normal skin and usual cutaneous carcinomas.J Cutan Pathol29,517-23(2002)Reis-Filho, JS., Schmitt, FC., Albergaria, A., Torio, B.
- Enrichment and identification of human 'fetal' epidermal stem cells.Hum Reprod19,968-74(2004)Cao, YJ., Chen, SY., Duan, EK., Zhou, JX., Liu, WM.

NUMB [plasma membrane] (Homo sapiens)

- Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis.Cell Transplant25,353-64(2016)Conaldi, PG., Sciuto, MR., Iannolo, G., Colarossi, C., De Maria, R., Memeo, L., Buccheri, S.

AQP3 [plasma membrane] (Homo sapiens)

- Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3.J Biol Chem277,17147-53(2002)Ma, T., Verkman, AS., Verbavatz, JM., Hara, M., Sougrat, R.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Functional expression of AQP3 in human skin epidermis and reconstructed epidermis.J Invest Dermatol118,678-85(2002)Gondran, C., Dumas, M., Gobin, R., Morand, M., Verbavatz, JM., Bonté, F., Barré, P., Sougrat, R.
- Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes.Biochim Biophys Acta1522,82-8(2001)Ota, Y., Sugiyama, Y., Inoue, S., Hara, M.

RNA

LRIG1 mRNA [cytosol] (Homo sapiens)

- Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.Proc Natl Acad Sci U S A103,11958-63(2006)Watt, FM., Jensen, KB.

COL17A1 mRNA [cytosol] (Homo sapiens)

- Single cell transcriptomics of human epidermis identifies basal stem cell transition states.Nat Commun11,4239(2020)MacLean, AL., Drummond, ML., Wu, SC., Gutierrez, G., That, BT., Atwood, SX., Stabell, AR., Benavente, CA., Wang, S., Nie, Q., Tarapore, E., Guerrero-Juarez, CF.
- Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment.Stem Cell Reports18,2047-2055(2023)Philippeos, C., Haniffa, M., Watt, FM., Ganier, C., Louis, B., Ali, S., Reynolds, G., Zijl, S., Negri, VA.

CSPG4 mRNA [cytosol] (Homo sapiens)

- Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.Proc Natl Acad Sci U S A103,11958-63(2006)Watt, FM., Jensen, KB.

Participates

as an input of

Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)

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