Reactome | Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex

Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex

Stable Identifier

R-HSA-2130279

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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General

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Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex

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B-TrCP associates with phosphorylated beta-catenin through the B-TrCP WD40 repeat region. Currently, it is unclear whether the ubiquitin ligase binds beta-catenin after it leaves the complex. It is equally possible that it binds beta-catenin while beta-catenin is still bound to Axin.

Literature References

PubMed ID	Title	Journal	Year
10023660	The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin Latres, E, Chiaur, DS, Pagano, M	Oncogene	1999
9990852	The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro Winston, JT, Strack, P, Beer-Romero, P, Chu, CY, Elledge, SJ, Harper, JW	Genes Dev	1999