Association of beta-catenin with the destruction complex

Stable Identifier
R-HSA-195304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Beta-catenin associates with the destruction complex through an interaction with Axin and or APC. This association may also involve interactions with the 15 aa repeats in APC (Spink et al., 2001) or the third APC 20aa repeat and its N-terminal flanking residues (Ha et al., 2004, Xing et al., 2004; Liu et al., 2006).

Literature References
PubMed ID Title Journal Year
15327769 Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function

Xing, Y, Clements, WK, Le Trong, I, Hinds, TR, Stenkamp, R, Kimelman, D, Xu, W

Mol Cell 2004
Participants
Participant Of
Orthologous Events
Reviewed
Created