Association of beta-catenin with the destruction complex

Stable Identifier
R-HSA-195304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Association of beta-catenin with the destruction complex
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Beta-catenin associates with the destruction complex through an interaction with Axin and or APC. This association may also involve interactions with the 15 aa repeats in APC (Spink et al., 2001) or the third APC 20aa repeat and its N-terminal flanking residues (Ha et al., 2004, Xing et al., 2004; Liu et al., 2006).
Literature References
PubMed ID Title Journal Year
15327769 Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function

Kimelman, D, Stenkamp, R, Hinds, TR, Xing, Y, Clements, WK, Le Trong, I, Xu, W

Mol Cell 2004
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Output
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as an event of
Orthologous Events
Association of beta-catenin with the destruction complex (Bos taurus)
Association of beta-catenin with the destruction complex (Caenorhabditis elegans)
Association of beta-catenin with the destruction complex (Canis familiaris)
Association of beta-catenin with the destruction complex (Drosophila melanogaster)
Association of beta-catenin with the destruction complex (Gallus gallus)
Association of beta-catenin with the destruction complex (Mus musculus)
Association of beta-catenin with the destruction complex (Rattus norvegicus)
Association of beta-catenin with the destruction complex (Sus scrofa)
Reviewed
Pagano, M  (2007-04-27)
Created
Matthews, L  (2007-04-03)
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