Beta-catenin phosphorylation cascade

Stable Identifier
R-HSA-196299
Type
Pathway
Species
Homo sapiens
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Degradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated phosphorylation at Thr41, Ser37 and Ser33 (Amit et al., 2002 ; Lui et al., 2002).

Literature References
PubMed ID Title Journal Year
12000790 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

Andersen, JS, Birman, Y, Mann, M, Ben-Shushan, E, Alkalay, I, Hatzubai, A, Amit, S, Ben-Neriah, Y

Genes Dev 2002
11955436 Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Zhang, Z, Baeg, GH, Lin, X, Tan, Y, Li, Y, He, X, Semenov, M, Han, C, Liu, C

Cell 2002
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Orthologous Events
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BioModels Database
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