Reactome | Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

Stable Identifier

R-HSA-196299

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

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Degradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated phosphorylation at Thr41, Ser37 and Ser33 (Amit et al., 2002 ; Lui et al., 2002).

Literature References

PubMed ID	Title	Journal	Year
11955436	Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism Liu, C, Li, Y, Semenov, M, Han, C, Baeg, GH, Tan, Y, Zhang, Z, Lin, X, He, X	Cell	2002
12000790	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway Amit, S, Hatzubai, A, Birman, Y, Andersen, JS, Ben-Shushan, E, Mann, M, Ben-Neriah, Y, Alkalay, I	Genes Dev	2002