Expression of AXIN1 gene

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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AXIN1 was first identified as the product of the mouse gene fused and has since been shown to have a key role in the degradation of beta-catenin by the destruction complex (Zeng et al, 1997; reviewed in Saito-Diaz et al, 2013). Deletion, missense and nonsense mutations that lead to activated WNT signaling have been identified in the AXIN1 gene in human cancers, making AXIN1 a tumor suppressor gene (reviewed in Salahshor and Woodgett, 2005).

Literature References
PubMed ID Title Journal Year
15735151 The links between axin and carcinogenesis

Salahshor, S, Woodgett, JR

J. Clin. Pathol. 2005
23256519 The way Wnt works: Components and mechanism

Wang, X, Wallace, HA, Page-McCaw, A, Lee, E, Thorne, CA, Chen, TW, Saito-Diaz, K

Growth Factors 2013
9230313 The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Gumbiner, BM, Hsu, W, Costantini, F, Zhang, T, Lee, JJ, Vasicek, TJ, Zeng, L, Fagotto, F, Tilghman, SM, Perry, WL

Cell 1997
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