Assembly of the destruction complex

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
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The exact composition of the destruction complex is not known. A number of components appear to form a core complex, while others may associate with the complex transiently when a Wnt signal is present (reviewed in Kimelman and Xu, 2006). The core components include Axin, glycogen synthase kinase 3 (GSK-3), Casein kinase 1 (CKI) alpha, beta-catenin, Protein phosphatase 2A (PP2A) and Adenomatous Polyposis Coli (APC). CK1 epsilon, Diversin and PP1 may also be components of the complex.
Literature References
PubMed ID Title Journal Year
12554650 Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

Roe, SM, Pearl, LH, Yeo, M, Fraser, E, Dajani, R, Dale, TC, Good, VM, Thompson, V

EMBO J 2003
10092233 Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

Gil, R, Virshup, DM, Miller, JR, White, R, Seeling, JM, Moon, RT

Science 1999
17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

Berndt, JD, Major, MB, Maccoss, MJ, Yi, X, Camp, ND, Biechele, TL, Hubbert, C, Gingras, AC, Angers, S, Zheng, N, Goldenberg, SJ, Moon, RT

Science 2007
Event Information
Orthologous Events
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