Reactome | Assembly of the destruction complex

Assembly of the destruction complex

Stable Identifier

R-HSA-195251

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The exact composition of the destruction complex is not known. A number of components appear to form a core complex, while others may associate with the complex transiently when a Wnt signal is present (reviewed in Kimelman and Xu, 2006). The core components include Axin, glycogen synthase kinase 3 (GSK-3), Casein kinase 1 (CKI) alpha, beta-catenin, Protein phosphatase 2A (PP2A) and Adenomatous Polyposis Coli (APC). CK1 epsilon, Diversin and PP1 may also be components of the complex.

Literature References

PubMed ID	Title	Journal	Year
12554650	Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex Dajani, R, Fraser, E, Roe, SM, Yeo, M, Good, VM, Thompson, V, Dale, TC, Pearl, LH	EMBO J	2003
10092233	Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A Seeling, JM, Miller, JR, Gil, R, Moon, RT, White, R, Virshup, DM	Science	1999
17510365	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling Major, MB, Camp, ND, Berndt, JD, Yi, X, Goldenberg, SJ, Hubbert, C, Biechele, TL, Gingras, AC, Zheng, N, Maccoss, MJ, Angers, S, Moon, RT	Science	2007