Expression of AMER1 gene

Stable Identifier
R-HSA-5251557
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Expression of AMER1 gene
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AMER1 was identified as a gene mutated in a subset of Wilms tumors (Rivera et al, 2007) and the protein has been shown to be a component of the beta-catenin destruction complex (Major et al, 2007).
Literature References
PubMed ID Title Journal Year
17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

Major, MB, Camp, ND, Berndt, JD, Yi, X, Goldenberg, SJ, Hubbert, C, Biechele, TL, Gingras, AC, Zheng, N, Maccoss, MJ, Angers, S, Moon, RT

Science 2007
17204608 An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

Rivera, MN, Kim, WJ, Wells, J, Driscoll, DR, Brannigan, BW, Han, M, Kim, JC, Feinberg, AP, Gerald, WL, Vargas, SO, Chin, L, Iafrate, AJ, Bell, DW, Haber, DA

Science 2007
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Authored
Rothfels, K  (2014-01-23)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2014-02-04)
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