Reactome | ID2 [nucleoplasm]

ID2 [nucleoplasm]

Stable Identifier

R-HSA-452391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA-binding protein inhibitor ID-2, ID2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)
        
        ID2, ID4 [nucleoplasm] (Homo sapiens)
        
        ID2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02363 ID2

Gene Names

ID2, BHLHB26

Chain

chain:1-134

Reference Genes

BioGPS Gene:3398 ID2

COSMIC (genes):ID2 ID2

CTD Gene:3398 ID2

dbSNP Gene:3398 ID2

ENSEMBL:ENSG00000115738.10 ID2

HGNC:5361 ID2

KEGG Gene (Homo sapiens):3398 ID2

Monarch:3398 ID2

NCBI Gene:3398 ID2

OMIM:600386 ID2

Reference Transcript

RefSeq:NM_002166.4 ID2

Other Identifiers

11715994_x_at

11746878_s_at

16876822

201565_PM_s_at

201565_s_at

201566_PM_x_at

2468693

2468694

2468697

2468698

2468699

2468701

2468703

2468704

2468705

2468706

2679302

2679305

3398

41215_s_at

41216_r_at

64354_f_at

8040103

A_23_P143143

GE81127

GO:0000122

GO:0000278

GO:0000791

GO:0002376

GO:0003013

GO:0003166

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006629

GO:0007507

GO:0007623

GO:0010628

GO:0010629

GO:0019216

GO:0021772

GO:0030154

GO:0032922

GO:0032991

GO:0033598

GO:0042752

GO:0043153

GO:0043226

GO:0043353

GO:0043433

GO:0044325

GO:0045475

GO:0045578

GO:0045600

GO:0045651

GO:0045664

GO:0045777

GO:0045892

GO:0045893

GO:0046983

GO:0048511

GO:0048557

GO:0048661

GO:0048663

GO:0048711

GO:0048856

GO:0051148

GO:0060749

GO:0061030

GO:0061031

GO:0061629

GO:0071931

GO:0090398

GO:0098772

GO:0140416

GO:2000045

GO:2000177

HMNXSV003013938

Hs.180919.1.A1_3p_a_at

ILMN_1793990

ILMN_2086095

M97796_s_at

PH_hs_0029349

TC02000041.hg

g4504570_3p_s_at

Participates

as a member of

ID2, ID4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_002157.2

OpenTargets

ENSG00000115738

HPA

ENSG00000115738-ID2

GeneCards

Q02363

Ensembl

ENSP00000234091, ENST00000396290, ENST00000234091, ENST00000331129, ENSG00000115738, ENSP00000379585, ENSP00000385465

PRO

Q02363

Pharos - Targets

Q02363

PDB

4AYA

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96HC4 PDLIM5	1	PDLIM5 [cytosol] (R-HSA-6794246)	0.633	5
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.573	2
UniProt:A6NI15 MSGN1	1	MSGN1 [nucleoplasm] (R-HSA-9793376)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9NW38 FANCL	1	FANCL [nucleoplasm] (R-HSA-419520)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3