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3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2173246
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
3x4Hyp-3Hyp-GalHyl-COL8A1, 3,4-Hyp 5-Gal-Hyl-collagen alpha-1(VIII) chain, 3,4-hydroxyprolyl-collagen alpha-1(VIII) chain, CO8A1_HUMAN, COL8A1
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)
COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Collagen chain trimerization (Homo sapiens)
Association of procollagen type VIII (Homo sapiens)
Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen type VIII trimer [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)
PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2 (Homo sapiens)
COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)
PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum membrane] (Homo sapiens)
Galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen triple helix formation (Homo sapiens)
Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Homo sapiens)
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens)
Tropocollagen type VIII [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Procollagen C-linked trimers [endoplasmic reticulum lumen] (Homo sapiens)
C-linked procollagen type VIII trimer [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
Secretion of collagens (Homo sapiens)
Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Homo sapiens)
Collagens and tropocollagens [endoplasmic reticulum lumen] (Homo sapiens)
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens)
Tropocollagen type VIII [endoplasmic reticulum lumen] (Homo sapiens)
Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27658 COL8A1
Gene Names
COL8A1, C3orf7
Chain
signal peptide:1-27, chain:28-744, chain:572-744
Reference Genes
BioGPS Gene:1295 COL8A1
COSMIC (genes):COL8A1 COL8A1
CTD Gene:1295 COL8A1
dbSNP Gene:1295 COL8A1
ENSEMBL:ENSG00000144810 COL8A1
ENSEMBL_homo_sapiens_GENE:ENSG00000144810.16 COL8A1
HGNC:2215 COL8A1
KEGG Gene (Homo sapiens):1295 COL8A1
Monarch:1295 COL8A1
NCBI Gene:1295 COL8A1
OMIM:120251 COL8A1
UCSC:P27658 COL8A1
Reference Transcript
RefSeq:NM_020351.3 COL8A1
RefSeq:NM_001850.4 COL8A1
Other Identifiers
11728809_a_at
1295
214587_PM_at
214587_at
226237_PM_at
226237_at
2633400
2633401
2633410
2633432
2633440
2633441
2633442
2633443
2633444
2633445
2633446
2633447
2633448
37459_at
52019_at
71929_at
85126_at
A_14_P129689
A_14_P134616
A_23_P211762
A_23_P69030
A_24_P139152
GE59827
GE79165
GO:0001525
GO:0001935
GO:0005198
GO:0005515
GO:0005576
GO:0005581
GO:0005591
GO:0005604
GO:0005615
GO:0005783
GO:0005788
GO:0007155
GO:0010811
GO:0030020
GO:0030154
GO:0030198
GO:0030312
GO:0031012
GO:0035987
GO:0043226
GO:0048593
GO:0048856
GO:0062023
HMNXSV003050033
Hs.114599.0.S2_3p_at
Hs.41271.0.S1_3p_at
ILMN_1685433
ILMN_2246563
ILMN_2402392
PH_hs_0006297
TC03000502.hg
Participates
as a candidate of
3,4-Hyp 5-Gal-Hyl collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
as a member of
Alpha-1(VIII) chains [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen]
5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL8A1(28-?) [extracellular region]
GalHyl-COL8A1(?-744) [extracellular region]
3x4Hyp-3Hyp-COL8A1(?-744) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL8A1(?-744) [extracellular region]
3x4Hyp-5Hyl-COL8A1(?-744) [extracellular region]
GalHyl-COL8A1(28-?) [extracellular region]
5Hyl-COL8A1(?-744) [extracellular region]
COL8A1(?-744) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL8A1(28-?) [extracellular region]
3x4Hyp-5Hyl-COL8A1(28-?) [extracellular region]
GlcGalHyl-COL8A1(28-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL8A1(?-744) [extracellular region]
3x4Hyp-GalHyl-COL8A1(28-?) [extracellular region]
5Hyl-COL8A1(28-?) [extracellular region]
3x4Hyp-COL8A1(28-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL8A1(?-744) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-?) [extracellular region]
COL8A1(28-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL8A1(28-?) [extracellular region]
3x4Hyp-GalHyl-COL8A1(?-744) [extracellular region]
3x4Hyp-GlcGalHyl-COL8A1(?-744) [extracellular region]
GalHyl-COL8A1(28-744) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [extracellular region]
COL8A1(28-744) [extracellular region]
5Hyl-COL8A1(28-744) [extracellular region]
3x4Hyp-3Hyp-COL8A1(28-744) [extracellular region]
3x4Hyp-GlcGalHyl-COL8A1(28-744) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [extracellular region]
3x4Hyp-COL8A1(?-744) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [extracellular region]
3x4Hyp-GalHyl-COL8A1(28-744) [extracellular region]
GlcGalHyl-COL8A1(28-744) [extracellular region]
3x4Hyp-5Hyl-COL8A1(28-744) [extracellular region]
3x4Hyp-GlcGalHyl-COL8A1(28-?) [extracellular region]
GlcGalHyl-COL8A1(?-744) [extracellular region]
Inferred To
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(Gallus gallus)
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(Sus scrofa)
Col8a1 [endoplasmic reticulum lumen]
(Mus musculus)
Col8a1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
Mp [endoplasmic reticulum lumen]
(Drosophila melanogaster)
COL8A1 [endoplasmic reticulum lumen]
(Bos taurus)
col8a1b [endoplasmic reticulum lumen]
(Danio rerio)
CMSS1 [endoplasmic reticulum lumen]
(Canis familiaris)
col-99 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,3S)-3-hydroxyproline at unknown position
PsiMod Name
(2S,3S)-3-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.
Name
O5-galactosyl-L-hydroxylysine at unknown position
PsiMod Name
O5-galactosyl-L-hydroxylysine
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.
Cross References
RefSeq
NP_001841.2
,
NP_065084.2
OpenTargets
ENSG00000144810
GeneCards
P27658
HPA
ENSG00000144810-COL8A1
Ensembl
ENSP00000261037
,
ENST00000273342
,
ENSP00000273342
,
ENSP00000498483
,
ENST00000652472
,
ENSG00000144810
,
ENST00000261037
PRO
P27658
Pharos - Targets
P27658
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
6
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
5
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
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