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GATA1 [nucleoplasm]
Stable Identifier
R-HSA-996772
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Erythroid transcription factor, GATA1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
RUNX1 binds the core TAL1 complex (Homo sapiens)
RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA1,GATA2,GATA3 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA1,GATA2,GATA3 [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
ZFPM proteins bind GATA proteins (Homo sapiens)
GATA proteins [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
ZFPM proteins:GATA proteins [nucleoplasm] (Homo sapiens)
GATA proteins [nucleoplasm] (Homo sapiens)
GATA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15976 GATA1
Gene Names
GATA1, ERYF1, GF1
Chain
chain:1-413
Reference Genes
BioGPS Gene:2623 GATA1
COSMIC (genes):GATA1 GATA1
CTD Gene:2623 GATA1
dbSNP Gene:2623 GATA1
ENSEMBL:ENSG00000102145 GATA1
ENSEMBL_homo_sapiens_GENE:ENSG00000102145.16 GATA1
HGNC:4170 GATA1
KEGG Gene (Homo sapiens):2623 GATA1
Monarch:2623 GATA1
NCBI Gene:2623 GATA1
OMIM:305371 GATA1
UCSC:P15976 GATA1
Reference Transcript
RefSeq:NM_002049.3 GATA1
Other Identifiers
11731813_a_at
11731814_at
11753147_a_at
1555590_3p_a_at
1555590_PM_a_at
1555590_a_at
17103440
210446_3p_at
210446_PM_at
210446_at
2623
36787_at
3976833
3976838
3976839
3976840
3976841
3976842
3976843
3976844
3976845
8167360
GE59746
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001221
GO:0001223
GO:0001228
GO:0001701
GO:0002039
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007155
GO:0007204
GO:0007267
GO:0008270
GO:0008283
GO:0008285
GO:0008584
GO:0009653
GO:0010559
GO:0010724
GO:0010725
GO:0012501
GO:0016192
GO:0017053
GO:0022414
GO:0023052
GO:0030099
GO:0030154
GO:0030218
GO:0030219
GO:0030220
GO:0030221
GO:0030222
GO:0030282
GO:0030502
GO:0031100
GO:0031490
GO:0032993
GO:0033028
GO:0033033
GO:0033687
GO:0033690
GO:0035162
GO:0035854
GO:0036211
GO:0042060
GO:0043066
GO:0043226
GO:0043306
GO:0043565
GO:0045165
GO:0045648
GO:0045893
GO:0045944
GO:0046872
GO:0048468
GO:0048731
GO:0048821
GO:0048856
GO:0048873
GO:0050731
GO:0060009
GO:0060319
GO:0061629
GO:0070527
GO:0070742
GO:0071222
GO:0071320
GO:0071372
GO:0097028
GO:0140110
GO:1901135
GO:1990837
GO:2000678
GO:2001240
HMNXSV003010910
Hs2.765.2.S1_3p_at
Hs2.765.2.S1_3p_s_at
ILMN_1797251
PH_hs_0000089
TC0X000260.hg
X17254_at
g183071_3p_at
g183071_3p_x_at
Participates
as a member of
GATA proteins [nucleoplasm] (Homo sapiens)
GATA1,GATA2,GATA3 [nucleoplasm] (Homo sapiens)
as a component of
GATA1:ZFPM1 [nucleoplasm] (Homo sapiens)
Inferred To
gata1a [nucleoplasm]
(Danio rerio)
Gata1 [nucleoplasm]
(Mus musculus)
Gata1 [nucleoplasm]
(Rattus norvegicus)
GATAe [nucleoplasm]
(Drosophila melanogaster)
GATAd [nucleoplasm]
(Drosophila melanogaster)
med-2 [nucleoplasm]
(Caenorhabditis elegans)
med-1 [nucleoplasm]
(Caenorhabditis elegans)
pnr [nucleoplasm]
(Drosophila melanogaster)
elt-7 [nucleoplasm]
(Caenorhabditis elegans)
elt-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of GATA1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of GATA1 [nucleoplasm]
(Danio rerio)
Homologues of GATA1 [nucleoplasm]
(Drosophila melanogaster)
Homologues of GATA1 [nucleoplasm]
(Xenopus tropicalis)
srp [nucleoplasm]
(Drosophila melanogaster)
elt-2 [nucleoplasm]
(Caenorhabditis elegans)
elt-6 [nucleoplasm]
(Caenorhabditis elegans)
gata4 [nucleoplasm]
(Danio rerio)
gata4 [nucleoplasm]
(Xenopus tropicalis)
GATA1 [nucleoplasm]
(Bos taurus)
GATA1 [nucleoplasm]
(Caenorhabditis elegans)
GATA1 [nucleoplasm]
(Canis familiaris)
GATA1 [nucleoplasm]
(Sus scrofa)
gata1 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of GATA1 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_002040.1
OpenTargets
ENSG00000102145
GeneCards
P15976
HPA
ENSG00000102145-GATA1
Ensembl
ENST00000376670
,
ENST00000651144
,
ENSP00000365858
,
ENSP00000498550
,
ENSG00000102145
PRO
P15976
Pharos - Targets
P15976
Orphanet
16102
PDB
6G0Q
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.582
6
UniProt:Q9H2U1 DHX36
1
DHX36 [cytosol]
(R-HSA-3134862)
0.569
4
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.556
3
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.508
2
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