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ADORA2A [Golgi membrane]
Stable Identifier
R-HSA-187668
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Adenosine A2a receptor, AA2A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Activation of TRKA receptors (Homo sapiens)
NGF-independant TRKA activation (Homo sapiens)
Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)
ADORA2A [Golgi membrane] (Homo sapiens)
Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane] (Homo sapiens)
ADORA2A [Golgi membrane] (Homo sapiens)
NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates (Homo sapiens)
Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane] (Homo sapiens)
ADORA2A [Golgi membrane] (Homo sapiens)
Ade-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2 [Golgi membrane] (Homo sapiens)
ADORA2A [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29274 ADORA2A
Gene Names
ADORA2A, ADORA2
Chain
chain:1-412
Reference Genes
BioGPS Gene:135 ADORA2A
COSMIC (genes):ADORA2A ADORA2A
CTD Gene:135 ADORA2A
dbSNP Gene:135 ADORA2A
ENSEMBL:ENSG00000128271 ADORA2A
HGNC:263 ADORA2A
KEGG:hsa:135 ADORA2A
Monarch:135 ADORA2A
NCBI Gene:135 ADORA2A
OMIM:102776 ADORA2A
UCSC:P29274 ADORA2A
Reference Transcript
RefSeq:NM_000675.5 ADORA2A
RefSeq:NM_001278500.1 ADORA2A
RefSeq:NM_001278499.1 ADORA2A
RefSeq:NM_001278497.1 ADORA2A
RefSeq:NM_001278498.1 ADORA2A
Other Identifiers
11721939_a_at
11749942_a_at
135
205013_PM_s_at
205013_s_at
32114_s_at
3940100
3940101
3940102
3940103
3940104
3940105
3940106
3940107
3940111
3940112
3940113
3940114
3940115
8071899
A_14_P105883
A_14_P130735
A_23_P109436
A_24_P237270
A_33_P3214035
GE59944
GO:0001609
GO:0001963
GO:0001973
GO:0001975
GO:0003013
GO:0003014
GO:0004930
GO:0005515
GO:0005516
GO:0005882
GO:0005886
GO:0006355
GO:0006909
GO:0006915
GO:0006954
GO:0006968
GO:0007186
GO:0007188
GO:0007189
GO:0007267
GO:0007271
GO:0007417
GO:0007596
GO:0007600
GO:0007626
GO:0008015
GO:0008092
GO:0008285
GO:0008289
GO:0009410
GO:0012501
GO:0014049
GO:0014057
GO:0014061
GO:0014074
GO:0016020
GO:0016192
GO:0019899
GO:0023052
GO:0030424
GO:0030425
GO:0030673
GO:0031000
GO:0031802
GO:0032230
GO:0032279
GO:0035249
GO:0035810
GO:0042311
GO:0042734
GO:0042755
GO:0042802
GO:0043025
GO:0043116
GO:0043279
GO:0043524
GO:0044877
GO:0045211
GO:0045938
GO:0046636
GO:0048143
GO:0048786
GO:0048812
GO:0048856
GO:0050714
GO:0050728
GO:0050877
GO:0051393
GO:0051881
GO:0051899
GO:0051924
GO:0051968
GO:0060079
GO:0060080
GO:0060089
GO:0060134
GO:0097190
GO:0098978
GO:0099171
GO:1900273
GO:2001235
HMNXSV003051303
ILMN_1671970
ILMN_1807372
PH_hs_0022955
TC22001457.hg
X68486_at
g5921991_3p_a_at
Participates
as an input of
Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)
as a component of
Ade-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2 [Golgi membrane] (Homo sapiens)
Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane] (Homo sapiens)
Other forms of this molecule
ADORA2A [plasma membrane]
Cross References
RefSeq
NP_001265427.1
,
NP_001265429.1
,
NP_000666.2
,
NP_001265426.1
,
NP_001265428.1
ZINC - World Drugs
AA2AR_HUMAN
Guide to Pharmacology - Targets
19
OpenTargets
ENSG00000128271
ENSEMBL
ENSP00000480012
,
ENSP00000336630
,
ENSP00000483102
,
ENSP00000481552
,
ENST00000610595
,
ENST00000618076
,
ENST00000337539
,
ENST00000611543
ZINC - FDA approved
AA2AR_HUMAN
ZINC - Substances
AA2AR_HUMAN
ZINC - Biogenic
AA2AR_HUMAN
ZINC target
P29274
PRO
P29274
GlyGen
P29274
PDB
3UZC
,
2YDV
,
5K2A
,
8GNG
,
8DU3
,
8A2P
,
5OM1
,
5IU7
,
8GNE
,
5OLG
,
3VG9
,
7EZC
,
5K2B
,
3PWH
,
3VGA
,
5K2C
,
6PS7
,
6LPJ
,
7PYR
,
6AQF
,
8CU7
,
5UIG
,
3QAK
,
6S0L
,
5NM4
,
2YDO
,
6WQA
,
8JWY
,
4UHR
,
5WF6
,
8WDT
,
5UVI
,
5OM4
,
5OLZ
,
8JWZ
,
7RM5
,
5JTB
,
5WF5
,
4UG2
,
8C9W
,
7ARO
,
5IU4
,
3EML
,
8RQQ
,
6GDG
,
5IU8
,
3RFM
,
5NLX
,
5OLO
,
6MH8
,
7T32
,
7PX4
,
5OLH
,
6S0Q
,
6LPL
,
5N2R
,
8A2O
,
3UZA
,
4EIY
,
5K2D
,
6JZH
,
5VRA
,
6ZDR
,
8PWN
,
3REY
,
5IUB
,
5IUA
,
5MZP
,
8CU6
,
5NM2
,
6ZDV
,
5G53
,
6LPK
,
5OLV
,
8CIC
,
5MZJ
,
6GT3
ZINC - Investigational
AA2AR_HUMAN
ZINC - Metabolites
AA2AR_HUMAN
HPA
ENSG00000128271-ADORA2A
Pharos - Targets
P29274
Orphanet
ADORA2A
ZINC - Predictions - Purchasable
AA2AR_HUMAN
HMDB Protein
HMDBP01652
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29274 ADORA2A
2
ADORA2A [plasma membrane]
(R-HSA-418934)
ADORA2A [Golgi membrane]
(R-HSA-187668)
0.748
8
UniProt:Q7Z6G3 NECA2
0.71
6
UniProt:P21554 CNR1
1
CNR1 [plasma membrane]
(R-HSA-419411)
0.683
8
UniProt:P14416 DRD2
1
DRD2 [plasma membrane]
(R-HSA-390816)
0.681
6
UniProt:Q99418 CYTH2
2
CYTH2 [cytosol]
(R-HSA-8847831)
CYTH2 [Golgi membrane]
(R-HSA-8847829)
0.634
6
UniProt:Q13107 USP4
1
USP4 [cytosol]
(R-HSA-5212663)
0.593
4
UniProt:Q5T9L3-1 WLS
0.589
3
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.581
3
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.556
3
UniProt:O43759-2 SYNGR1
0.556
3
UniProt:P29275 ADORA2B
1
ADORA2B [plasma membrane]
(R-HSA-418898)
0.535
5
UniProt:P30542 ADORA1
1
ADORA1 [plasma membrane]
(R-HSA-418941)
0.518
4
UniProt:P31424-1 GRM5
0.463
3
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