Reactome | ADORA2A [Golgi membrane]

ADORA2A [Golgi membrane]

Stable Identifier

R-HSA-187668

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Adenosine A2a receptor, AA2A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P29274 ADORA2A

Gene Names

ADORA2A, ADORA2

Chain

chain:1-412

Reference Genes

BioGPS Gene:135 ADORA2A

COSMIC (genes):ADORA2A ADORA2A

CTD Gene:135 ADORA2A

dbSNP Gene:135 ADORA2A

ENSEMBL:ENSG00000128271 ADORA2A

HGNC:263 ADORA2A

KEGG Gene (Homo sapiens):135 ADORA2A

Monarch:135 ADORA2A

NCBI Gene:135 ADORA2A

OMIM:102776 ADORA2A

Reference Transcript

Other Identifiers

11721939_a_at

11749942_a_at

135

205013_s_at

32114_s_at

3940102

3940103

3940104

3940105

3940106

3940107

3940111

3940112

3940113

3940114

3940115

8071899

A_23_P109436

A_24_P237270

A_33_P3214035

GE59944

GO:0000139

GO:0000902

GO:0001609

GO:0001963

GO:0001973

GO:0001975

GO:0002376

GO:0003013

GO:0003674

GO:0004930

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005856

GO:0005882

GO:0005886

GO:0005887

GO:0006355

GO:0006464

GO:0006469

GO:0006810

GO:0006909

GO:0006915

GO:0006950

GO:0006954

GO:0006968

GO:0007155

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007205

GO:0007267

GO:0007271

GO:0007417

GO:0007596

GO:0007600

GO:0007626

GO:0008015

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0012505

GO:0014049

GO:0014057

GO:0014061

GO:0014069

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0019899

GO:0030154

GO:0030424

GO:0030425

GO:0030673

GO:0031000

GO:0031802

GO:0032230

GO:0032279

GO:0034641

GO:0035249

GO:0035810

GO:0035815

GO:0040011

GO:0040013

GO:0042311

GO:0042493

GO:0042592

GO:0042734

GO:0042755

GO:0042802

GO:0043025

GO:0043116

GO:0043154

GO:0043226

GO:0043279

GO:0043524

GO:0044267

GO:0044877

GO:0045211

GO:0045938

GO:0046636

GO:0048143

GO:0048786

GO:0048812

GO:0048856

GO:0050714

GO:0050728

GO:0050877

GO:0051393

GO:0051881

GO:0051899

GO:0051924

GO:0051968

GO:0060079

GO:0060080

GO:0060134

GO:0098978

GO:0099055

GO:0099056

GO:1900273

GO:2000300

GO:2001235

ILMN_1807372

PH_hs_0022955

TC22001457.hg

X68486_at

g5921991_3p_a_at

Participant Of

input

Ade-Rib binds AODORA2A and NTRK1,2

hasComponent

Other forms of this molecule

ADORA2A [plasma membrane]

Cross References

RefSeq

NP_000666.2, NP_001265427.1, NP_001265429.1, NP_001265428.1, NP_001265426.1

ZINC - World Drugs

AA2AR_HUMAN

OpenTargets

ENSG00000128271

ZINC - FDA approved

AA2AR_HUMAN

ZINC - Substances

AA2AR_HUMAN

ZINC - Biogenic

AA2AR_HUMAN

ZINC target

P29274

PRO

P29274

PDB

6PS7, 2YDO, 1UPE, 5IU8, 5UIG, 2YDV, 3QAK, 4UG2, 5UVI, 5IUA, 6GT3, 6MH8, 5OLH, 3VG9, 4EIY, 5WF6, 5OLG, 4UHR, 3UZC, 5VRA, 5IU7, 5IU4, 3PWH, 3VGA, 5OLO, 6JZH, 5WF5, 3EML, 3UZA, 3RFM, 5OLV, 5JTB, 5G53, 5K2D, 5NLX, 5NM2, 5OM4, 5OLZ, 5OM1, 5MZJ, 5K2A, 5NM4, 5N2R, 1MMH, 5IUB, 5MZP, 5K2C, 5K2B, 3REY, 6GDG, 6AQF

ZINC - Investigational

AA2AR_HUMAN

ZINC - Metabolites

AA2AR_HUMAN

HPA

ENSG00000128271-ADORA2A

GeneCards

P29274

Ensembl

ENSG00000128271, ENSP00000336630, ENST00000618076, ENSP00000483102, ENSP00000481552, ENSP00000480012, ENST00000611543, ENST00000610595, ENST00000337539

Orphanet

22401

ZINC - Predictions - Purchasable

AA2AR_HUMAN

HMDB Protein

HMDBP01652

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29274 ADORA2A	2	ADORA2A [plasma membrane] (R-HSA-418934) ADORA2A [Golgi membrane] (R-HSA-187668)	0.779	8
UniProt:P21554 CNR1	1	CNR1 [plasma membrane] (R-HSA-419411)	0.75	8
UniProt:P14416 DRD2	1	DRD2 [plasma membrane] (R-HSA-390816)	0.734	4
UniProt:Q7Z6G3 NECA2			0.71	6
UniProt:Q99418 CYTH2	2	CYTH2 [Golgi membrane] (R-HSA-8847829) CYTH2 [cytosol] (R-HSA-8847831)	0.645	6
UniProt:P29275 ADORA2B	1	ADORA2B [plasma membrane] (R-HSA-418898)	0.625	5
UniProt:Q13107 USP4	1	USP4 [cytosol] (R-HSA-5212663)	0.593	4
UniProt:O15354 GPR37	1	GPR37 [plasma membrane] (R-HSA-5333623)	0.581	3
UniProt:O43759-2 SYNGR1			0.556	3
UniProt:P30542 ADORA1	1	ADORA1 [plasma membrane] (R-HSA-418941)	0.556	4
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.556	3
UniProt:P0DP23 CALM1	5	Me3K115-CALM1 [cytosol] (R-HSA-9016706) CALM1 [extracellular region] (R-HSA-9016841) CALM1 [plasma membrane] (R-HSA-9016884) CALM1 [nucleoplasm] (R-HSA-9016871) CALM1 [cytosol] (R-HSA-9016707)	0.537	3
UniProt:P31424-1 GRM5			0.463	3