Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ADORA1 [plasma membrane]
Stable Identifier
R-HSA-418941
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Adenosine receptor A1, AA1R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Nucleotide-like (purinergic) receptors (Homo sapiens)
Adenosine P1 receptors (Homo sapiens)
A1 and A3 receptors bind adenosine (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
ADORA1,3 [plasma membrane] (Homo sapiens)
ADORA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30542 ADORA1
Gene Names
ADORA1
Chain
chain:1-326
Reference Genes
BioGPS Gene:134 ADORA1
COSMIC (genes):ADORA1 ADORA1
CTD Gene:134 ADORA1
dbSNP Gene:134 ADORA1
ENSEMBL:ENSG00000163485 ADORA1
HGNC:262 ADORA1
KEGG:hsa:134 ADORA1
Monarch:134 ADORA1
NCBI Gene:134 ADORA1
OMIM:102775 ADORA1
UCSC:P30542 ADORA1
Reference Transcript
RefSeq:NM_001048230.1 ADORA1
RefSeq:NM_000674.2 ADORA1
Other Identifiers
11726657_a_at
11726658_a_at
11747699_a_at
134
16676130
205481_PM_at
205481_at
216220_PM_s_at
216220_s_at
2375597
2375603
2375604
2375605
2375606
2375608
2375609
2375610
2375612
2375613
2375618
2375619
2375623
2375624
2375625
2375626
2375627
40400_at
7908907
A_23_P74299
GE57678
GO:0001609
GO:0001659
GO:0001664
GO:0001666
GO:0001883
GO:0001973
GO:0002087
GO:0002376
GO:0002674
GO:0002686
GO:0002793
GO:0003013
GO:0003014
GO:0003084
GO:0003085
GO:0003093
GO:0004930
GO:0005515
GO:0005886
GO:0006612
GO:0006629
GO:0006909
GO:0006954
GO:0007165
GO:0007186
GO:0007193
GO:0007267
GO:0007399
GO:0008285
GO:0014050
GO:0014074
GO:0016020
GO:0016042
GO:0016192
GO:0016323
GO:0023052
GO:0030425
GO:0030673
GO:0031072
GO:0031683
GO:0032229
GO:0032244
GO:0032279
GO:0032795
GO:0032900
GO:0035307
GO:0042311
GO:0042321
GO:0042323
GO:0042734
GO:0043025
GO:0043066
GO:0043195
GO:0043197
GO:0043268
GO:0043410
GO:0044297
GO:0044305
GO:0044877
GO:0045202
GO:0045211
GO:0045776
GO:0045777
GO:0046888
GO:0046982
GO:0048786
GO:0048856
GO:0048870
GO:0050728
GO:0050877
GO:0050890
GO:0050900
GO:0050965
GO:0050995
GO:0050996
GO:0051930
GO:0051967
GO:0055089
GO:0055117
GO:0060079
GO:0060089
GO:0060292
GO:0070254
GO:0070256
GO:0070328
GO:0086004
GO:0097190
GO:0099509
GO:1900272
GO:1900453
HMNXSV003019930
Hs.77867.1.S1_3p_a_at
ILMN_1747227
ILMN_1895120
ILMN_2275396
ILMN_2373444
L22214_at
PH_hs_0004494
TC01001683.hg
g4501946_3p_at
Participates
as a member of
ADORA1,3 [plasma membrane] (Homo sapiens)
Inferred To
Adora1 [plasma membrane]
(Mus musculus)
Adora1 [plasma membrane]
(Rattus norvegicus)
ADORA1 [plasma membrane]
(Bos taurus)
ADORA1 [plasma membrane]
(Caenorhabditis elegans)
ADORA1 [plasma membrane]
(Canis familiaris)
ADORA1 [plasma membrane]
(Gallus gallus)
ADORA1 [plasma membrane]
(Sus scrofa)
Homologues of ADORA1 [plasma membrane]
(Caenorhabditis elegans)
gtr-1 [plasma membrane]
(Caenorhabditis elegans)
AdoR [plasma membrane]
(Drosophila melanogaster)
ador-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001041695.1
,
NP_000665.1
ZINC - World Drugs
AA1R_HUMAN
Guide to Pharmacology - Targets
18
ENSEMBL
ENST00000337894
,
ENSP00000356205
,
ENST00000309502
,
ENSP00000356204
,
ENST00000367236
,
ENST00000367235
,
ENSP00000338435
,
ENSP00000308549
OpenTargets
ENSG00000163485
ZINC - FDA approved
AA1R_HUMAN
ZINC - Substances
AA1R_HUMAN
ZINC - Biogenic
AA1R_HUMAN
ZINC target
P30542
PRO
P30542
PDB
6D9H
,
7LD4
,
7LD3
,
5UEN
,
5N2S
ZINC - Investigational
AA1R_HUMAN
ZINC - Metabolites
AA1R_HUMAN
HPA
ENSG00000163485-ADORA1
Pharos - Targets
P30542
ZINC - Predictions - Purchasable
AA1R_HUMAN
HMDB Protein
HMDBP01650
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07550 ADRB2
5
ADRB2 [plasma membrane]
(R-HSA-390647)
pS-ADRB2 [plasma membrane]
(R-HSA-8852158)
PolyUb-ADRB2 [endosome membrane]
(R-HSA-6783066)
ADRB2 [endosome membrane]
(R-HSA-6783036)
pS-ADRB2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869143)
0.61
5
UniProt:P08588 ADRB1
1
ADRB1 [plasma membrane]
(R-HSA-390653)
0.61
5
UniProt:P29274 ADORA2A
2
ADORA2A [plasma membrane]
(R-HSA-418934)
ADORA2A [Golgi membrane]
(R-HSA-187668)
0.518
4
UniProt:P16473 TSHR
1
TSHR [plasma membrane]
(R-HSA-391371)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text