Ade-Rib binds AODORA2A and NTRK1,2

Stable Identifier
R-HSA-187661
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
ReviewStatus
5/5
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Ade-Rib binds AODORA2A and NTRK1,2
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. First, Ade-Rib binds ADORA2A and NTRK1 and NTRK2.
Participants
Input
Output
Participates
as an event of
Inferred From
TrkA activation by adenosine A2a receptor (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Created
Jassal, B  (2006-09-21)
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