Ade-Rib binds AODORA2A and NTRK1,2

Stable Identifier
R-HSA-187661
Type
Reaction [binding]
Species
Homo sapiens
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. First, Ade-Rib binds ADORA2A and NTRK1 and NTRK2.

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