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CNR1 [plasma membrane]
Stable Identifier
R-HSA-419411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cannabinoid receptor 1, CNR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
CNRs bind CNR agonists (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
CNRs:CNR agonists [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
Cannabinoid receptors can bind cannabinoids (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
CNRs:Cannabinoids [plasma membrane] (Homo sapiens)
CNRs [plasma membrane] (Homo sapiens)
CNR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21554 CNR1
Gene Names
CNR1, CNR
Chain
chain:1-472
Reference Genes
BioGPS Gene:1268 CNR1
COSMIC (genes):CNR1 CNR1
CTD Gene:1268 CNR1
dbSNP Gene:1268 CNR1
ENSEMBL:ENSG00000118432 CNR1
ENSEMBL_homo_sapiens_GENE:ENSG00000118432.13 CNR1
HGNC:2159 CNR1
KEGG Gene (Homo sapiens):1268 CNR1
Monarch:1268 CNR1
NCBI Gene:1268 CNR1
OMIM:114610 CNR1
Reference Transcript
RefSeq:NM_001160259.1 CNR1
RefSeq:XM_006715330.3 CNR1
RefSeq:XM_011535426.1 CNR1
RefSeq:XM_017010239.1 CNR1
RefSeq:NM_001160258.1 CNR1
RefSeq:NM_033181.3 CNR1
RefSeq:XM_011535425.1 CNR1
RefSeq:XM_017010238.1 CNR1
RefSeq:NM_016083.4 CNR1
RefSeq:NM_001160226.1 CNR1
RefSeq:XM_011535424.1 CNR1
RefSeq:XM_011535428.1 CNR1
RefSeq:XM_017010240.1 CNR1
Other Identifiers
11731615_s_at
11742193_a_at
1268
17021504
17021510
207940_PM_x_at
207940_x_at
208243_PM_s_at
208243_s_at
213436_PM_at
213436_at
2963860
2963861
2963862
2963863
2963864
2963865
2963866
2963867
2963876
2963879
2963880
36906_at
8128043
A_23_P214208
A_24_P363259
GE59384
GO:0002376
GO:0002866
GO:0003013
GO:0004930
GO:0004949
GO:0005515
GO:0005737
GO:0005739
GO:0005741
GO:0005856
GO:0005886
GO:0006629
GO:0006954
GO:0007165
GO:0007186
GO:0007187
GO:0007188
GO:0007189
GO:0007283
GO:0007413
GO:0007584
GO:0007611
GO:0007613
GO:0010976
GO:0012501
GO:0014063
GO:0015629
GO:0016020
GO:0019216
GO:0019222
GO:0022414
GO:0023052
GO:0030154
GO:0030424
GO:0030426
GO:0031622
GO:0031999
GO:0032228
GO:0032496
GO:0033004
GO:0033602
GO:0035094
GO:0038171
GO:0042220
GO:0042593
GO:0042734
GO:0042802
GO:0042995
GO:0043065
GO:0043226
GO:0043271
GO:0045121
GO:0045202
GO:0045471
GO:0045759
GO:0045776
GO:0045777
GO:0048856
GO:0050796
GO:0050877
GO:0051966
GO:0055065
GO:0060089
GO:0060135
GO:0060259
GO:0060405
GO:0098793
GO:0098921
GO:0098978
GO:0098982
GO:0099509
GO:0099553
HMNXSV003010221
HMNXSV003012528
Hs.75110.1.S1_3p_at
ILMN_1813581
PH_hs_0004276
TC06001932.hg
TC06003758.hg
TC06003759.hg
U73304_rna1_at
g4502926_3p_a_at
g7705313_3p_s_at
Participates
as a member of
CNRs [plasma membrane] (Homo sapiens)
Inferred To
Cnr1 [plasma membrane]
(Mus musculus)
Cnr1 [plasma membrane]
(Rattus norvegicus)
CNR1 [plasma membrane]
(Bos taurus)
CNR1 [plasma membrane]
(Gallus gallus)
CNR1 [plasma membrane]
(Sus scrofa)
cnr1 [plasma membrane]
(Danio rerio)
cnr1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016865729.1
,
NP_001153730.1
,
NP_001153731.1
,
XP_011533728.1
,
XP_011533730.1
,
XP_006715393.1
,
XP_016865727.1
,
XP_011533727.1
,
XP_011533726.1
,
NP_149421.2
,
NP_057167.2
,
NP_001153698.1
,
XP_016865728.1
ZINC - World Drugs
CNR1_HUMAN
Guide to Pharmacology - Targets
56
OpenTargets
ENSG00000118432
ZINC - FDA approved
CNR1_HUMAN
ZINC - Substances
CNR1_HUMAN
ZINC target
P21554
ZINC - Biogenic
CNR1_HUMAN
PRO
P21554
PDB
5TGZ
,
8WU1
,
8GAG
,
8WRZ
,
7V3Z
,
5U09
,
1LVR
,
2MZA
,
5XR8
,
8K8J
,
6KQI
,
2B0Y
,
2KOE
,
6N4B
,
1LVQ
,
8GHV
,
2MZ2
,
6KPG
,
7FEE
,
7WV9
,
5XRA
,
2MZ3
ZINC - Investigational
CNR1_HUMAN
ZINC - Metabolites
CNR1_HUMAN
HPA
ENSG00000118432-CNR1
GeneCards
P21554
Ensembl
ENST00000468898
,
ENST00000549890
,
ENSP00000420188
,
ENSP00000446702
,
ENSP00000412192
,
ENST00000428600
,
ENST00000551417
,
ENST00000369499
,
ENST00000369501
,
ENSG00000118432
,
ENSP00000446819
,
ENSP00000358511
,
ENSP00000358513
Pharos - Targets
P21554
Orphanet
28454
ZINC - Predictions - Purchasable
CNR1_HUMAN
HMDB Protein
HMDBP10803
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29274 ADORA2A
2
ADORA2A [Golgi membrane]
(R-HSA-187668)
ADORA2A [plasma membrane]
(R-HSA-418934)
0.683
8
UniProt:P14416 DRD2
1
DRD2 [plasma membrane]
(R-HSA-390816)
0.471
3
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