Reactome | USP4 [cytosol]

USP4 [cytosol]

Stable Identifier

R-HSA-5212663

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13107 USP4

Gene Names

USP4, UNP, UNPH

Chain

chain:1-963

Reference Genes

BioGPS Gene:7375 USP4

COSMIC (genes):USP4 USP4

CTD Gene:7375 USP4

dbSNP Gene:7375 USP4

ENSEMBL:ENSG00000114316 USP4

ENSEMBL:ENSG00000114316.13 USP4

HGNC:12627 USP4

KEGG Gene (Homo sapiens):7375 USP4

Monarch:7375 USP4

NCBI Gene:7375 USP4

OMIM:603486 USP4

UCSC:Q13107 USP4

Reference Transcript

Other Identifiers

11720344_s_at

11720345_a_at

1357_at

16954003

16954013

202681_PM_at

202681_at

202682_PM_s_at

202682_s_at

211800_PM_s_at

211800_s_at

2674173

2674174

2674175

2674176

2674178

2674180

2674181

2674182

2674186

2674187

2674188

2674189

2674190

2674191

2674192

2674193

2674194

2674195

2674197

2674198

2674199

2674200

2674202

2674203

2674204

2674218

2674220

2674222

2674223

2674225

2674226

2674227

37339_at

7375

8087374

8087380

A_23_P80891

A_24_P291598

GE59002

GO:0000244

GO:0003824

GO:0004843

GO:0005515

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006508

GO:0006511

GO:0008233

GO:0008234

GO:0016071

GO:0016579

GO:0016787

GO:0030163

GO:0031397

GO:0031647

GO:0031685

GO:0034394

GO:0036211

GO:0042802

GO:0043226

GO:0046872

GO:0065003

GO:0140096

HMNXSV003026928

HMNXSV003051068

Hs.77500.0.S2_3p_at

ILMN_1773505

ILMN_1798712

PH_hs_0004467

TC03003383.hg

U20657_at

g2656142_3p_a_at

Participates

as a member of

USP4,USP25 [cytosol] (Homo sapiens)

as a component of

USP4:PolyUb-TRAF2, PolyUb-TRAF6 [cytosol] (Homo sapiens)

as a candidate of

RIPK1 deubiquitinases [cytosol] (Homo sapiens)

Inferred To

usp-4 [cytosol] (Caenorhabditis elegans)

USP4 [cytosol] (Bos taurus)

USP4 [cytosol] (Canis familiaris)

USP4 [cytosol] (Danio rerio)

USP4 [cytosol] (Dictyostelium discoideum)

USP4 [cytosol] (Gallus gallus)

USP4 [cytosol] (Mus musculus)

USP4 [cytosol] (Rattus norvegicus)

USP4 [cytosol] (Sus scrofa)

usp4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003354.2, NP_001238806.1, NP_955475.1

OpenTargets

ENSG00000114316

ZINC - Substances

UBP4_HUMAN

HPA

ENSG00000114316-USP4

GeneCards

Q13107

ZINC target

Q13107

Ensembl

ENST00000351842, ENSP00000265560, ENSP00000341028, ENST00000416417, ENSP00000400623, ENSG00000114316, ENST00000265560

PRO

Q13107

Pharos - Targets

Q13107

PDB

5CTR, 2Y6E

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29274 ADORA2A	2	ADORA2A [Golgi membrane] (R-HSA-187668) ADORA2A [plasma membrane] (R-HSA-418934)	0.593	4
UniProt:Q13107 USP4	1	USP4 [cytosol] (R-HSA-5212663)	0.558	3
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.524	4

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