Reactome | CYTH2 [cytosol]

CYTH2 [cytosol]

Stable Identifier

R-HSA-8847831

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ARNO, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Intra-Golgi traffic (Homo sapiens)
      - CYTH proteins bind ARF1:GTP (Homo sapiens)
        
        CYTH1,2,3,4 [cytosol] (Homo sapiens)
        
        CYTH2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99418 CYTH2

Gene Names

CYTH2, ARNO, PSCD2, PSCD2L

Chain

chain:1-400

Reference Genes

BioGPS Gene:9266 CYTH2

COSMIC (genes):CYTH2 CYTH2

CTD Gene:9266 CYTH2

dbSNP Gene:9266 CYTH2

ENSEMBL:ENSG00000105443 CYTH2

HGNC:9502 CYTH2

KEGG:hsa:9266 CYTH2

Monarch:9266 CYTH2

NCBI Gene:9266 CYTH2

OMIM:602488 CYTH2

UCSC:Q99418 CYTH2

Reference Transcript

Other Identifiers

11716316_x_at

11716317_at

11761298_at

1555842_PM_at

1555842_at

16863799

209158_PM_s_at

209158_s_at

237234_PM_at

237234_at

3837837

3837838

3837839

3837840

3837841

3837842

3837843

3837844

3837845

3837846

3837847

3837848

3837849

3837850

3837851

3837852

3837853

3837854

3837855

3837856

3837858

3837859

3837860

3837861

3837862

3837863

3837864

38741_at

76157_at

8030049

8030064

9266

A_14_P102961

A_23_P119377

A_24_P374918

GE79784

GO:0000139

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005912

GO:0005923

GO:0006897

GO:0007010

GO:0008289

GO:0016020

GO:0016192

GO:0030036

GO:0030426

GO:0032012

GO:0042995

GO:0070679

GO:0098772

HMNXSV003024776

HMNXSV003043894

Hs.119761.0.A1_3p_at

Hs2.399807.1.S1_3p_at

Hs2.399807.1.S1_3p_x_at

ILMN_1721241

ILMN_2377459

PH_hs_0000903

PH_hs_0039437

TC19000704.hg

U59752_at

g13279334_3p_s_at

Participates

as a member of

CYTH1,2,3,4 [cytosol] (Homo sapiens)

Other forms of this molecule

CYTH2 [Golgi membrane]

Inferred To

Homologues of CYTH2 [cytosol] (Dictyostelium discoideum)

Homologues of CYTH2 [cytosol] (Schizosaccharomyces pombe)

CYTH2 [cytosol] (Canis familiaris)

CYTH2 [cytosol] (Dictyostelium discoideum)

CYTH2 [cytosol] (Mus musculus)

CYTH2 [cytosol] (Rattus norvegicus)

CYTH2 [cytosol] (Saccharomyces cerevisiae)

CYTH2 [cytosol] (Schizosaccharomyces pombe)

CYTH2 [cytosol] (Sus scrofa)

step [cytosol] (Drosophila melanogaster)

sec72 [cytosol] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENSG00000105443, ENSP00000493357, ENSP00000408236, ENST00000641098, ENST00000452733

OpenTargets

ENSG00000105443

GeneCards

CYTH2

HPA

ENSG00000105443-CYTH2

ZINC - Substances

CYH2_HUMAN

ZINC target

Q99418

PRO

Q99418

Pharos - Targets

Q99418

HMDB Protein

HMDBP08339

PDB

4JMO, 1R8S, 1S9D, 1R8M, 4JMI, 1PBV, 4Z21, 1R8Q, 4JXH, 4JWL, 4L5M

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84077 ARF1	2	ARF1 [Golgi membrane] (R-HSA-199971) ARF1 [cytosol] (R-HSA-200826)	0.722	5
UniProt:P29274 ADORA2A	2	ADORA2A [plasma membrane] (R-HSA-418934) ADORA2A [Golgi membrane] (R-HSA-187668)	0.634	6