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CYTH2 [Golgi membrane]
Stable Identifier
R-HSA-8847829
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
ARNO, Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, PH, SEC7 and coiled-coil domain-containing protein 2
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
CYTH proteins bind ARF1:GTP (Homo sapiens)
ARF1:GTP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH2 [Golgi membrane] (Homo sapiens)
CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)
ARF1:GDP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH2 [Golgi membrane] (Homo sapiens)
ARF1:GTP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH2 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99418 CYTH2
Gene Names
CYTH2, ARNO, PSCD2, PSCD2L
Chain
chain:1-400
Reference Genes
BioGPS Gene:9266 CYTH2
COSMIC (genes):CYTH2 CYTH2
CTD Gene:9266 CYTH2
dbSNP Gene:9266 CYTH2
ENSEMBL:ENSG00000105443 CYTH2
ENSEMBL_homo_sapiens_GENE:ENSG00000105443.17 CYTH2
HGNC:9502 CYTH2
KEGG Gene (Homo sapiens):9266 CYTH2
Monarch:9266 CYTH2
NCBI Gene:9266 CYTH2
OMIM:602488 CYTH2
UCSC:Q99418 CYTH2
Reference Transcript
RefSeq:NM_017457.5 CYTH2
RefSeq:NM_004228.6 CYTH2
Other Identifiers
11716316_x_at
11716317_at
1555842_PM_at
1555842_at
209158_PM_s_at
209158_s_at
3837838
3837840
3837841
3837842
3837844
3837847
3837849
3837850
3837852
3837855
3837856
3837858
3837859
3837860
3837861
3837862
3837863
3837864
38741_at
8030049
8030064
9266
A_23_P119377
GE79784
GO:0000139
GO:0005085
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005912
GO:0005923
GO:0006897
GO:0007010
GO:0008289
GO:0016020
GO:0016192
GO:0023052
GO:0030036
GO:0030426
GO:0032012
GO:0042995
GO:0043226
GO:0070161
GO:0070679
GO:0098772
HMNXSV003024776
Hs2.399807.1.S1_3p_at
Hs2.399807.1.S1_3p_x_at
ILMN_1721241
ILMN_2377459
PH_hs_0000903
PH_hs_0039437
U59752_at
g13279334_3p_s_at
Participates
as a member of
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
Other forms of this molecule
CYTH2 [cytosol]
Inferred To
SEC7 [Golgi membrane]
(Saccharomyces cerevisiae)
step [Golgi membrane]
(Drosophila melanogaster)
sec71 [Golgi membrane]
(Schizosaccharomyces pombe)
sec72 [Golgi membrane]
(Schizosaccharomyces pombe)
CYTH2 [Golgi membrane]
(Canis familiaris)
CYTH2 [Golgi membrane]
(Dictyostelium discoideum)
CYTH2 [Golgi membrane]
(Mus musculus)
CYTH2 [Golgi membrane]
(Rattus norvegicus)
CYTH2 [Golgi membrane]
(Sus scrofa)
Homologues of CYTH2 [Golgi membrane]
(Dictyostelium discoideum)
Homologues of CYTH2 [Golgi membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_004219.3
,
NP_059431.1
OpenTargets
ENSG00000105443
GeneCards
Q99418
HPA
ENSG00000105443-CYTH2
ZINC target
Q99418
Ensembl
ENSP00000408236
,
ENSP00000493357
,
ENSG00000105443
,
ENST00000452733
,
ENST00000641098
PRO
Q99418
Pharos - Targets
Q99418
HMDB Protein
HMDBP08339
PDB
4JMI
,
1S9D
,
1R8M
,
1PBV
,
4Z21
,
1R8S
,
4JMO
,
4L5M
,
1R8Q
,
4JXH
,
4JWL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P84077 ARF1
2
ARF1 [cytosol]
(R-HSA-200826)
ARF1 [Golgi membrane]
(R-HSA-199971)
0.722
5
UniProt:P29274 ADORA2A
2
ADORA2A [Golgi membrane]
(R-HSA-187668)
ADORA2A [plasma membrane]
(R-HSA-418934)
0.634
6
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