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DRD2 [plasma membrane]
Stable Identifier
R-HSA-390816
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Dopamine receptor 2, RecName: Full=D, DRD2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Dopamine receptors (Homo sapiens)
DRD2 antagonist drugs bind to DRD2 (Homo sapiens)
DRD2 [plasma membrane] (Homo sapiens)
DRD2:DRD2 antagonists [plasma membrane] (Homo sapiens)
DRD2 [plasma membrane] (Homo sapiens)
DRD2 binds DA (Homo sapiens)
DRD2 [plasma membrane] (Homo sapiens)
DRD2:DA [plasma membrane] (Homo sapiens)
DRD2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14416 DRD2
Gene Names
DRD2
Chain
chain:1-443
Reference Genes
BioGPS Gene:1813 DRD2
COSMIC (genes):DRD2 DRD2
CTD Gene:1813 DRD2
dbSNP Gene:1813 DRD2
ENSEMBL:ENSG00000149295 DRD2
HGNC:3023 DRD2
KEGG:hsa:1813 DRD2
Monarch:1813 DRD2
NCBI Gene:1813 DRD2
OMIM:126450 DRD2
UCSC:P14416 DRD2
Reference Transcript
RefSeq:NM_016574.3 DRD2
RefSeq:XM_017017296.1 DRD2
RefSeq:NM_000795.3 DRD2
Other Identifiers
11730479_a_at
11730480_a_at
16744461
1813
206590_PM_x_at
206590_x_at
211624_PM_s_at
211624_s_at
216924_PM_s_at
216924_s_at
216938_PM_x_at
216938_x_at
3391652
3391654
3391655
3391656
3391657
3391658
3391659
3391660
3391661
3391662
3391663
3391664
3391665
3391666
3391668
3391669
3391670
3391671
3391672
3391673
3391680
3391681
3391682
3391683
40371_at
7951703
A_24_P283834
A_33_P3733417
GE59752
GO:0000139
GO:0001591
GO:0001659
GO:0001666
GO:0001669
GO:0001764
GO:0001963
GO:0001964
GO:0001965
GO:0001975
GO:0001976
GO:0002027
GO:0002028
GO:0002031
GO:0002052
GO:0002092
GO:0003012
GO:0003014
GO:0004930
GO:0004952
GO:0005102
GO:0005515
GO:0005794
GO:0005886
GO:0005929
GO:0006355
GO:0006874
GO:0006914
GO:0007186
GO:0007188
GO:0007194
GO:0007195
GO:0007200
GO:0007212
GO:0007270
GO:0007405
GO:0007409
GO:0007416
GO:0007608
GO:0007616
GO:0007625
GO:0007626
GO:0007628
GO:0007631
GO:0008104
GO:0008283
GO:0008285
GO:0008306
GO:0008542
GO:0009410
GO:0009416
GO:0009636
GO:0010039
GO:0014059
GO:0014854
GO:0015459
GO:0016020
GO:0016055
GO:0016192
GO:0016328
GO:0016477
GO:0021756
GO:0021769
GO:0021853
GO:0021984
GO:0023052
GO:0030139
GO:0030336
GO:0030424
GO:0030425
GO:0030432
GO:0030534
GO:0030672
GO:0030900
GO:0031223
GO:0031410
GO:0032228
GO:0032355
GO:0032467
GO:0032795
GO:0032922
GO:0033602
GO:0034330
GO:0034776
GO:0035094
GO:0035240
GO:0035255
GO:0035556
GO:0035810
GO:0035815
GO:0036126
GO:0040018
GO:0042220
GO:0042321
GO:0042417
GO:0042734
GO:0042756
GO:0042802
GO:0043197
GO:0043204
GO:0043226
GO:0043266
GO:0043278
GO:0043408
GO:0043410
GO:0043473
GO:0043491
GO:0043679
GO:0044877
GO:0045202
GO:0045211
GO:0045471
GO:0045745
GO:0045776
GO:0045824
GO:0045944
GO:0046676
GO:0046717
GO:0048148
GO:0048149
GO:0048169
GO:0048678
GO:0048755
GO:0048856
GO:0048870
GO:0050482
GO:0050673
GO:0050680
GO:0050709
GO:0050769
GO:0050804
GO:0050805
GO:0050877
GO:0051209
GO:0051481
GO:0051580
GO:0051583
GO:0051584
GO:0051586
GO:0051823
GO:0051898
GO:0051967
GO:0055085
GO:0060079
GO:0060089
GO:0060124
GO:0060134
GO:0060158
GO:0060160
GO:0060170
GO:0070374
GO:0071300
GO:0071361
GO:0071880
GO:0090325
GO:0097159
GO:0097648
GO:0097730
GO:0098691
GO:0098772
GO:0098978
GO:0098982
GO:0099170
GO:0099171
GO:1900038
GO:1900168
GO:1900273
GO:1901363
GO:1903530
GO:1990384
GO:2001223
HMNXSV003046114
Hs.73893.1.A1_3p_a_at
Hs.73893.2.A1_3p_a_at
ILMN_1658214
ILMN_1675057
ILMN_2401494
M30625_s_at
PH_hs_0004224
TC11002302.hg
TC11003349.hg
X51362_s_at
g181431_3p_s_at
g4503384_3p_x_at
p26631
Participates
as a component of
DRD2:DA [plasma membrane] (Homo sapiens)
DRD2:DRD2 antagonists [plasma membrane] (Homo sapiens)
as an input of
DRD2 binds DA (Homo sapiens)
DRD2 antagonist drugs bind to DRD2 (Homo sapiens)
Inferred To
Drd2 [plasma membrane]
(Mus musculus)
Drd2 [plasma membrane]
(Rattus norvegicus)
DRD2 [plasma membrane]
(Bos taurus)
DRD2 [plasma membrane]
(Canis familiaris)
DRD2 [plasma membrane]
(Gallus gallus)
DRD2 [plasma membrane]
(Sus scrofa)
dop-3 [plasma membrane]
(Caenorhabditis elegans)
drd2b [plasma membrane]
(Danio rerio)
Dop2R [plasma membrane]
(Drosophila melanogaster)
Cross References
ZINC - World Drugs
DRD2_HUMAN
Guide to Pharmacology - Targets
215
OpenTargets
ENSG00000149295
ENSEMBL
ENST00000346454
,
ENSP00000278597
,
ENSP00000438215
,
ENST00000538967
,
ENST00000362072
,
ENSP00000354859
,
ENSP00000442172
,
ENST00000542968
ZINC - FDA approved
DRD2_HUMAN
ZINC - Substances
DRD2_HUMAN
ZINC - Biogenic
DRD2_HUMAN
ZINC target
P14416
PRO
P14416
GlyGen
P14416
PDB
6CM4
,
6LUQ
,
7DFP
,
6VMS
,
5AER
,
7JVR
,
8IRS
ZINC - Investigational
DRD2_HUMAN
ZINC - Metabolites
DRD2_HUMAN
HPA
ENSG00000149295-DRD2
Pharos - Targets
P14416
Orphanet
DRD2
ZINC - Predictions - Purchasable
DRD2_HUMAN
HMDB Protein
HMDBP01737
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14416 DRD2
1
DRD2 [plasma membrane]
(R-HSA-390816)
0.767
9
UniProt:P29274 ADORA2A
2
ADORA2A [plasma membrane]
(R-HSA-418934)
ADORA2A [Golgi membrane]
(R-HSA-187668)
0.681
6
UniProt:Q9NRI5 DISC1
0.544
3
UniProt:Q01959 SLC6A3
5
SLC6A3 [plasma membrane]
(R-HSA-379482)
SLC6A3 L368Q [plasma membrane]
(R-HSA-5660710)
SLC6A3 L224P [plasma membrane]
(R-HSA-5660718)
SLC6A3 P395L [plasma membrane]
(R-HSA-5660716)
SLC6A3 R521W [plasma membrane]
(R-HSA-5660729)
0.524
4
UniProt:Q99720 SIGMAR1
1
SIGMAR1 [cytosol]
(R-HSA-9679757)
0.518
5
UniProt:P21554 CNR1
1
CNR1 [plasma membrane]
(R-HSA-419411)
0.471
3
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