Reactome | EGFR binds EPS15, EPN1, EPS15L1

EGFR binds EPS15, EPN1, EPS15L1

Stable Identifier

R-HSA-8867044

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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EH-containing proteins such as EPS15, EPN1 and EPS15L1 are required for the endocytosis of ligand-activated EGFR (Confalonieri et al, 2000; Huang et al, 2004; reviewed in van Bergen en Henegouwen, 2009). EPS15 and EPN1 bind components of the clathrin coated pit through DPF motifs and likely bind to EGFR through the ubiquitin interacting motifs (UIMs). In this way EH proteins may help cluster activated EGFR into nascent clathrin-coated pits (Kazazic et al, 2009; Benmerah et al, 2000; reviewed in van Bergen en Henegouwen, 2009). Note, however, that EH-containing proteins are also involved in the clathrin-independent endocytosis of EGFR (Sigismund et al, 2005)

Literature References

PubMed ID	Title	Journal	Year
19814798	Eps15: a multifunctional adaptor protein regulating intracellular trafficking van Bergen En Henegouwen, PM	Cell Commun. Signal	2009
10652316	Mapping of Eps15 domains involved in its targeting to clathrin-coated pits Benmerah, A, Poupon, V, Cerf-Bensussan, N, Dautry-Varsat, A	J. Biol. Chem.	2000
14985334	Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference Huang, F, Khvorova, A, Marshall, W, Sorkin, A	J. Biol. Chem.	2004
10953014	Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis Confalonieri, S, Salcini, AE, Puri, C, Tacchetti, C, Di Fiore, PP	J. Cell Biol.	2000
19054389	Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits Kazazic, M, Bertelsen, V, Pedersen, KW, Vuong, TT, Grandal, MV, Rødland, MS, Traub, LM, Stang, E, Madshus, IH	Traffic	2009
15701692	Clathrin-independent endocytosis of ubiquitinated cargos Sigismund, S, Woelk, T, Puri, C, Maspero, E, Tacchetti, C, Transidico, P, Di Fiore, PP, Polo, S	Proc Natl Acad Sci U S A	2005