Reactome | EGFR non-clathrin mediated endocytosis

EGFR non-clathrin mediated endocytosis

Stable Identifier

R-HSA-183072

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1045 phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin.

Literature References

PubMed ID	Title	Journal	Year
15701692	Clathrin-independent endocytosis of ubiquitinated cargos Sigismund, S, Woelk, T, Puri, C, Maspero, E, Tacchetti, C, Transidico, P, Di Fiore, PP, Polo, S	Proc Natl Acad Sci U S A	2005
12072436	A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination Klapisz, E, Sorokina, I, Lemeer, S, Pijnenburg, M, Verkleij, AJ, van Bergen en Henegouwen, PM	J Biol Chem	2002