EGFR non-clathrin mediated endocytosis

Stable Identifier
Reaction [binding]
Homo sapiens
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At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1045 phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin.

Literature References
PubMed ID Title Journal Year
12072436 A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination

Pijnenburg, M, Lemeer, S, van Bergen en Henegouwen, PM, Sorokina, I, Klapisz, E, Verkleij, AJ

J Biol Chem 2002
15701692 Clathrin-independent endocytosis of ubiquitinated cargos

Di Fiore, PP, Tacchetti, C, Transidico, P, Puri, C, Maspero, E, Polo, S, Sigismund, S, Woelk, T

Proc Natl Acad Sci U S A 2005
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