Reactome | EGFR non-clathrin mediated endocytosis

EGFR non-clathrin mediated endocytosis

Stable Identifier

R-HSA-183072

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1069 (i.e. Y1045 in the mature protein) phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin.

Literature References

PubMed ID	Title	Journal	Year
12072436	A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination Klapisz, E, Sorokina, I, Lemeer, S, Pijnenburg, M, Verkleij, AJ, van Bergen en Henegouwen, PM	J Biol Chem	2002
15701692	Clathrin-independent endocytosis of ubiquitinated cargos Sigismund, S, Woelk, T, Puri, C, Maspero, E, Tacchetti, C, Transidico, P, Di Fiore, PP, Polo, S	Proc Natl Acad Sci U S A	2005