EGFR non-clathrin mediated endocytosis

Stable Identifier
R-HSA-183072
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1069 (i.e. Y1045 in the mature protein) phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin.
Literature References
PubMed ID Title Journal Year
12072436 A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination

Pijnenburg, M, Lemeer, S, van Bergen en Henegouwen, PM, Sorokina, I, Klapisz, E, Verkleij, AJ

J Biol Chem 2002
15701692 Clathrin-independent endocytosis of ubiquitinated cargos

Di Fiore, PP, Tacchetti, C, Transidico, P, Puri, C, Maspero, E, Polo, S, Sigismund, S, Woelk, T

Proc Natl Acad Sci U S A 2005
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