Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH

Stable Identifier
R-HSA-9866132
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
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The Intermediate II complex ("early core") binds the Complex III subunits CYC1, UQCRC1, UQCRC2, and UQCRH, releasing UQCC3 (Guo et al., 2017; reviewed in Ndi et al., 2018; Zara et al., 2022). UQCRHL, a human paralog of UQCRH that is 97% identical, may also funciton in complex III assembly and is annotated as a candidate (Luo et al, 2020). This assembly step is inferred from its equivalent in yeast.
Literature References
PubMed ID Title Journal Year
32929120 UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells

Luo, Y, Medina Bengtsson, L, Wang, X, Huang, T, Liu, G, Murphy, S, Wang, C, Koren, J, Schafer, Z, Lu, X

Sci Rep 2020
36142449 Assembly of the Multi-Subunit Cytochrome bc1 Complex in the Yeast Saccharomyces cerevisiae

Zara, V, De Blasi, G, Ferramosca, A

Int J Mol Sci 2022
28844695 Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2

Guo, R, Zong, S, Wu, M, Gu, J, Yang, M

Cell 2017
29733856 Biogenesis of the bc1 Complex of the Mitochondrial Respiratory Chain

Ndi, M, Marin-Buera, L, Salvatori, R, Singh, AP, Ott, M

J Mol Biol 2018
Participants
Input
Output
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as an event of
Catalyst Activity

protein binding activity of Intermediate II [mitochondrial inner membrane]

Physical Entity
Intermediate II [mitochondrial inner membrane] (Homo sapiens)
Activity
protein binding (GO:0005515)
Inferred From
CYTB:QCR7:QCR8 binds CYT1, COR1, COR2, QCR6 (Saccharomyces cerevisiae)
Authored
Stephan, R  (2024-03-22)
Reviewed
Hill, DP  (2024-05-16)
D'Eustachio, P  (2025-02-27)
Created
Stephan, R  (2024-03-22)
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