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CACNA1A [plasma membrane]
Stable Identifier
R-HSA-210490
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CaV2.1 P/Q type alpha 1 subunit of VCGG, Voltage-gated Calcium Channel Cav2.1-1 (alpha-1 subunit)
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)
Voltage-gated Calcium Channels (pancreatic beta cell) [plasma membrane] (Homo sapiens)
Voltage-gated Calcium Channel, P,Q-type 2.1 [plasma membrane] (Homo sapiens)
CACNA1A [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Presynaptic depolarization and calcium channel opening (Homo sapiens)
Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)
Voltage Gated Ca2+ Channel [plasma membrane] (Homo sapiens)
calcium channel multimer of P/Q type VGCC [plasma membrane] (Homo sapiens)
CACNA1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00555 CACNA1A
Gene Names
CACNA1A, CACH4, CACN3, CACNL1A4
Chain
chain:1-2506
Reference Genes
BioGPS Gene:773 CACNA1A
COSMIC (genes):CACNA1A CACNA1A
CTD Gene:773 CACNA1A
dbSNP Gene:773 CACNA1A
ENSEMBL:ENSG00000141837 CACNA1A
HGNC:1388 CACNA1A
KEGG:hsa:773 CACNA1A
Monarch:773 CACNA1A
NCBI Gene:773 CACNA1A
OMIM:601011 CACNA1A
UCSC:O00555 CACNA1A
Reference Transcript
RefSeq:NM_000068.3 CACNA1A
RefSeq:NM_001127222.1 CACNA1A
RefSeq:NM_023035.2 CACNA1A
RefSeq:NM_001127221.1 CACNA1A
RefSeq:NM_001174080.1 CACNA1A
Other Identifiers
11729989_a_at
11729990_x_at
11729991_at
1558944_PM_at
1558944_at
1558945_PM_s_at
1558945_s_at
16869427
16869479
17122062
206399_PM_x_at
206399_x_at
210770_PM_s_at
210770_s_at
214933_PM_at
214933_at
2406504
3708155
3852134
3852135
3852136
3852137
3852138
3852139
3852140
3852141
3852142
3852143
3852144
3852145
3852146
3852147
3852148
3852151
3852152
3852153
3852154
3852155
3852156
3852157
3852159
3852160
3852161
3852162
3852163
3852164
3852165
3852166
3852167
3852168
3852169
3852170
3852171
3852172
3852173
3852174
3852175
3852176
3852177
3852178
3852179
3852180
3852181
3852182
3852183
3852184
3852185
3852186
3852189
3852190
3852191
3852192
3852193
3852194
3852195
3852197
3852198
3852200
3852202
3852203
3852204
3852205
3852206
3852207
3852210
3852212
3852213
3852214
3852215
3852216
3852217
3852218
3852219
3852220
3852221
3852223
3852224
3852225
3852226
3852227
3852228
3852232
3852233
3852234
3852236
3852254
3852255
3852256
3852266
3852267
3852268
3852269
3852271
3852272
3852278
3852279
3852280
3852282
41052_s_at
51418_at
52775_at
64620_at
69923_at
773
8034643
ADDON000450.hg
ADDON002032.hg
A_21_P0009656
A_21_P0011722
A_24_P130559
A_33_P3275846
GO:0001540
GO:0005215
GO:0005216
GO:0005245
GO:0005262
GO:0005515
GO:0005634
GO:0005737
GO:0005886
GO:0005891
GO:0006811
GO:0007204
GO:0007268
GO:0008331
GO:0016020
GO:0019905
GO:0023052
GO:0034220
GO:0034702
GO:0042995
GO:0043025
GO:0043226
GO:0045202
GO:0046872
GO:0050804
GO:0055085
GO:0070588
GO:0098703
GO:1904645
GO:1904646
HMNXSV003000269
HMNXSV003010002
HMNXSV003040154
HMNXSV003046378
Hs.96253.2.S1_3p_at
Hs2.386291.1.A1_3p_at
ILMN_1684407
ILMN_1761851
ILMN_2340815
PH_hs_0028329
PH_hs_0034156
TC19001220.hg
TC19001222.hg
TC19002345.hg
TC19002346.hg
U79667_s_at
X99897_s_at
g13386497_3p_a_at
g2213912_3p_a_at
p25095
Participates
as a component of
Voltage-gated Calcium Channel, P,Q-type 2.1 [plasma membrane] (Homo sapiens)
calcium channel multimer of P/Q type VGCC [plasma membrane] (Homo sapiens)
Inferred To
CACNA1A [plasma membrane]
(Caenorhabditis elegans)
CACNA1A [plasma membrane]
(Canis familiaris)
CACNA1A [plasma membrane]
(Drosophila melanogaster)
CACNA1A [plasma membrane]
(Mus musculus)
CACNA1A [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001167551.1
,
NP_001120693.1
,
NP_001120694.1
,
NP_075461.2
,
NP_000059.3
Guide to Pharmacology - Targets
532
ENSEMBL
ENSP00000353362
,
ENST00000637276
,
ENST00000360228
,
ENST00000638009
,
ENSP00000490617
,
ENSP00000489777
,
ENSP00000489913
,
ENST00000637432
OpenTargets
ENSG00000141837
ZINC - Substances
CAC1A_HUMAN
ZINC target
O00555
PRO
O00555
GlyGen
O00555
PDB
8X90
,
8X93
,
8X91
,
3BXK
HPA
ENSG00000141837-CACNA1A
Pharos - Targets
O00555
Orphanet
CACNA1A
ZINC - Predictions - Purchasable
CAC1A_HUMAN
HMDB Protein
HMDBP07491
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22695 UQCRC2
1
UQCRC2 [mitochondrial inner membrane]
(R-HSA-164280)
0.508
2
UniProt:Q8N2S1 LTBP4
1
LTBP4 [extracellular region]
(R-HSA-2161309)
0.508
2
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