Reactome | FGFR2b Y376C [plasma membrane]

FGFR2b Y376C [plasma membrane]

Stable Identifier

R-HSA-1637931

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FGFR2-3 Y376C mutant

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Literature References

PubMed ID	Title	Journal	Year
17525745	Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes Pollock, PM, Gartside, MG, Dejeza, LC, Powell, MA, Mallon, MA, Davies, H, Mohammadi, M, Futreal, PA, Stratton, MR, Trent, JM, Goodfellow, PJ	Oncogene	2007
18552176	Drug-sensitive FGFR2 mutations in endometrial carcinoma Dutt, A, Salvesen, HB, Chen, TH, Ramos, AH, Onofrio, RC, Hatton, C, Nicoletti, R, Winckler, W, Grewal, R, Hanna, M, Wyhs, N, Ziaugra, L, Richter, DJ, Trovik, J, Engelsen, IB, Stefansson, IM, Fennell, T, Cibulskis, K, Zody, MC, Akslen, LA, Gabriel, S, Wong, KK, Sellers, WR, Meyerson, M, Greulich, H	Proc Natl Acad Sci U S A	2008
20106510	FGFR2 mutations are rare across histologic subtypes of ovarian cancer Byron, SA, Gartside, MG, Wellens, CL, Goodfellow, PJ, Birrer, MJ, Campbell, IG, Pollock, PM	Gynecol Oncol	2010

External Reference Information

External Reference

UniProt:P21802-3 FGFR2

Gene Names

FGFR2, BEK, KGFR, KSAM

Participates

as a component of

FGFR2b Y376C mutant dimer [plasma membrane] (Homo sapiens)

as a candidate of

FGFR2 ligand-independent mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-8Y-FGFR2-3 [plasma membrane]

FGFR2b long [plasma membrane]

p-8Y-FGFR2b C382R [plasma membrane]

p-8Y-FGFR2b S376C [plasma membrane]

p-8Y-FGFR2b S373C [plasma membrane]

p-8Y-FGFR2b P253R [plasma membrane]

p-8Y-FGFR2b S252W [plasma membrane]

FGFR2b C382R [plasma membrane]

FGFR2b S373C [plasma membrane]

FGFR2b P253R [plasma membrane]

FGFR2b S252W [plasma membrane]

Modified Residues

Name

L-tyrosine 376 replaced with L-cysteine

Coordinate

376

PsiMod

L-tyrosine removal [MOD:01649]

A protein modification that effectively removes or replaces an L-tyrosine.

L-cysteine residue [MOD:00014]

A protein modification that effectively converts a source amino acid residue to an L-cysteine.

Disease

Name	Identifier	Synonyms
female reproductive endometrioid cancer	DOID:3001	endometrioid tumor (morphologic abnormality), endometrioid neoplasm
ovarian cancer	DOID:2394	ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001138389.1, NP_001138388.1, NP_001138391.1, NP_075259.4, NP_001307583.1, NP_001307587.1, NP_001138385.1, NP_001138390.1, NP_000132.3, NP_001138387.1, NP_001138386.1, NP_075418.1

ZINC - World Drugs

FGFR2_HUMAN

Guide to Pharmacology - Targets

1809

OpenTargets

ENSG00000066468

ENSEMBL

ENSP00000358057, ENST00000351936, ENSP00000358056, ENSP00000353262, ENST00000369061, ENST00000683211, ENST00000369060, ENSP00000263451, ENST00000356226, ENSP00000507633, ENST00000357555, ENST00000358487, ENST00000346997, ENST00000369056, ENST00000359354, ENST00000457416, ENSP00000508257, ENSP00000348559, ENSP00000410294, ENST00000682550, ENSP00000309878, ENSP00000350166, ENSP00000351276, ENSP00000358052, ENSG00000066468, ENSP00000352309, ENST00000360144

Mondo

0002480

ZINC - FDA approved

FGFR2_HUMAN

ZINC - Substances

FGFR2_HUMAN

ZINC - Biogenic

FGFR2_HUMAN

ZINC target

P21802

PRO

P21802

PDB

4J98, 4J96, 6V6Q, 7KIA, 6LVK, 8U1F, 2PZR, 1DJS, 1WVZ, 3EUU, 4J99, 2PVY, 1OEC, 2FDB, 4J23, 5UGL, 2Q0B, 5UGX, 8W2X, 3RI1, 1IIL, 5UI0, 2PZ5, 3CLY, 5EG3, 4WV1, 8STG, 8W3D, 8H75, 3CAF, 1NUN, 1EV2, 4J97, 7KIE, 6LVL, 3DAR, 3B2T, 2PZP, 3OJM, 2PSQ, 7OZY, 2PY3, 4J95, 8SWE, 3OJ2, 2PWL, 5UHN, 8W38, 1GJO, 6AGX, 8W3B, 1E0O, 3CU1, 8E1X, 1II4, 2PVF

ZINC - Investigational

FGFR2_HUMAN

COSMIC

COSM41290, COSV60640350

IntEnz

2.7.10.1

GeneCards

FGFR2

HPA

ENSG00000066468-FGFR2

Pharos - Targets

P21802

Orphanet

FGFR2

ZINC - Predictions - Purchasable

FGFR2_HUMAN

HMDB Protein

HMDBP01305

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09038 FGF2	1	FGF2(143-288) [extracellular region] (R-HSA-189898)	0.779	5
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.745	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.735	6
ChEBI:73280 SSR			0.683	8
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.675	3
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.623	3
UniProt:O15520 FGF10	1	FGF10 [extracellular region] (R-HSA-189869)	0.571	2
UniProt:P06734 FCER2	1	FCER2(1-321) [plasma membrane] (R-HSA-2127280)	0.558	2
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.528	3
UniProt:Q3MIR4 CC50B			0.527	2
UniProt:O60637 TSN3			0.527	2
UniProt:Q96LL9 DJC30			0.527	2
UniProt:Q6P047 CH074			0.527	2
UniProt:Q99732 LITAF			0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q5T9A4 ATAD3B	3	ATAD3B [secretory granule membrane] (R-HSA-6801313) ATAD3B [plasma membrane] (R-HSA-6806518) ATAD3B [ficolin-1-rich granule membrane] (R-HSA-6801277)	0.527	2
UniProt:Q96HB5 CC120			0.527	2
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	2
UniProt:Q92551 IP6K1	2	IP6K1 [cytosol] (R-HSA-1604591) IP6K1 [nucleoplasm] (R-HSA-2023952)	0.527	2
UniProt:Q6P995 F171B			0.527	2
UniProt:Q92575 UBXN4			0.527	2
UniProt:Q96L94 SNX22			0.527	2
UniProt:Q96G30 MRAP2			0.527	2
UniProt:P55899 FCGRN			0.527	2
UniProt:Q5TF58 IFFO2			0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.527	2
UniProt:P01033 TIMP1	4	p-TIMP1 [endoplasmic reticulum lumen] (R-HSA-8957082) TIMP1 [endoplasmic reticulum lumen] (R-HSA-8956691) TIMP1 [extracellular region] (R-HSA-349743) TIMP1 [platelet alpha granule lumen] (R-HSA-349745)	0.527	2
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.519	2
UniProt:Q9ULH0 KIDINS220	2	p-Y1095-KIDINS220 [cytosol] (R-HSA-169869) KIDINS220 [cytosol] (R-HSA-169880)	0.483	2
UniProt:Q9UBH6 S53A1			0.483	2
UniProt:Q86VI4 LAP4B			0.463	2

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