CCNE1 gene transcription is stimulated by E2F1

Stable Identifier
R-HSA-8961846
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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CCNE1 gene transcription is stimulated by E2F1
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E2F1 directly stimulates transcription of the CCNE1 gene, encoding cyclin E1 (DeGregori et al. 1995, Ohtani et al. 1995).Cyclin E proteins play an important role in the transition from G1 to S-phase by associating with CDK2.

Literature References
PubMed ID Title Journal Year
8618861 Regulation of the cyclin E gene by transcription factor E2F1

Nevins, JR, DeGregori, J, Ohtani, K

Proc Natl Acad Sci U S A 1995
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

Nevins, JR, DeGregori, J, Kowalik, T

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
E2F1:TFDP1,TFDP2:CCNE1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-06)
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