E2F1 directly stimulates transcription of the CCNE1 gene, encoding cyclin E1 (DeGregori et al. 1995, Ohtani et al. 1995).Cyclin E proteins play an important role in the transition from G1 to S-phase by associating with CDK2.
DeGregori, J, Kowalik, T, Nevins, JR
Ohtani, K, DeGregori, J, Nevins, JR
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