CCNE1 gene transcription is stimulated by E2F1

Stable Identifier
R-HSA-8961846
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CCNE1 gene transcription is stimulated by E2F1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F1 directly stimulates transcription of the CCNE1 gene, encoding cyclin E1 (DeGregori et al. 1995, Ohtani et al. 1995).Cyclin E proteins play an important role in the transition from G1 to S-phase by associating with CDK2.

Literature References
PubMed ID Title Journal Year
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
8618861 Regulation of the cyclin E gene by transcription factor E2F1

Ohtani, K, DeGregori, J, Nevins, JR

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-06)