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DLL1 [plasma membrane]
Stable Identifier
R-HSA-157089
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Delta 1 ligand
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Expression of DLL1 in paraxial mesoderm (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Somitogenesis (Homo sapiens)
Expression of DLL1 in presomitic mesoderm (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Kidney development (Homo sapiens)
Nephron development (Homo sapiens)
Expression of DLL1 during nephron development (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)
NOTCH1 HD domain mutant fragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] (Homo sapiens)
DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] (Homo sapiens)
DLL1:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)
DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)
NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)
Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 fragment [plasma membrane] (Homo sapiens)
NOTCH1 fragment:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 PEST domain mutants bind DLL1 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)
DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates transcription of neuronal ligands (Homo sapiens)
DLL1 gene expression is inhibited by MECP2 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)
Ub-DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 fragment [plasma membrane] (Homo sapiens)
NOTCH1 fragment:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLL1 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
DLL1 binds NOTCH2 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH2 binds DLL/JAG ligand in cis (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH2:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)
NOTCH2 fragment:DLL/JAG [plasma membrane] (Homo sapiens)
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH2NLB, (NOTCH2NLA, NOTCH2NLC) bind DLL1, (DLL4, JAG1, JAG2) (Homo sapiens)
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC):DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)
DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NOTCH3 binds DLL1 (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH3 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)
DLL/JAG:NOTCH3 [plasma membrane] (Homo sapiens)
DLL1:NOTCH3 [plasma membrane] (Homo sapiens)
DLL1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00548 DLL1
Gene Names
DLL1, UNQ146/PRO172
Chain
signal peptide:1-17, chain:18-723
Reference Genes
BioGPS Gene:28514 DLL1
COSMIC (genes):DLL1 DLL1
CTD Gene:28514 DLL1
dbSNP Gene:28514 DLL1
ENSEMBL:ENSG00000198719 DLL1
HGNC:2908 DLL1
KEGG:hsa:28514 DLL1
Monarch:28514 DLL1
NCBI Gene:28514 DLL1
OMIM:606582 DLL1
UCSC:O00548 DLL1
Reference Transcript
RefSeq:NM_005618.3 DLL1
Other Identifiers
11724937_a_at
11724938_at
17025989
224215_PM_s_at
224215_s_at
227938_PM_s_at
227938_s_at
28514
2986362
2986363
2986364
2986366
2986367
2986368
2986369
2986370
2986372
2986374
2986376
2986377
2986379
2986380
2986381
2986382
2986383
2986384
2986385
2986386
2986387
2986388
2986389
2986390
2986391
2986392
2986393
8130939
GE81534
GO:0001709
GO:0001756
GO:0001757
GO:0001947
GO:0002085
GO:0002315
GO:0002376
GO:0003323
GO:0005112
GO:0005509
GO:0005515
GO:0005576
GO:0005886
GO:0005912
GO:0006355
GO:0007154
GO:0007219
GO:0007267
GO:0007275
GO:0007368
GO:0007386
GO:0008217
GO:0008284
GO:0008285
GO:0009954
GO:0010628
GO:0014002
GO:0014807
GO:0016020
GO:0016192
GO:0016324
GO:0021510
GO:0021688
GO:0021693
GO:0023052
GO:0030097
GO:0030099
GO:0030154
GO:0030155
GO:0030182
GO:0030857
GO:0030947
GO:0030957
GO:0031410
GO:0032502
GO:0032693
GO:0034351
GO:0035265
GO:0040008
GO:0042386
GO:0042491
GO:0043226
GO:0045121
GO:0045596
GO:0045605
GO:0045608
GO:0045611
GO:0045638
GO:0045662
GO:0045665
GO:0045746
GO:0045747
GO:0045807
GO:0045944
GO:0046331
GO:0048018
GO:0048630
GO:0048631
GO:0048633
GO:0048665
GO:0048839
GO:0048856
GO:0050767
GO:0051302
GO:0060041
GO:0060042
GO:0060563
GO:0060853
GO:0070161
GO:0070986
GO:0072006
GO:0072014
GO:0072070
GO:0072583
GO:0097009
GO:0097102
GO:0097110
GO:0097150
GO:0098772
GO:0098773
GO:1900746
GO:1903672
GO:2000726
HMNXSV003022644
Hs.250500.2.S1_3p_a_at
ILMN_1743373
PH_hs_0024078
TC06002342.hg
g6180181_3p_a_at
Participates
as a component of
DLL1:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
DLL1:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH3 [plasma membrane] (Homo sapiens)
DLL1:NOTCH2 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
as an input of
NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)
NOTCH3 binds DLL1 (Homo sapiens)
NOTCH1 binds DLL1 (Homo sapiens)
DLL1 binds NOTCH2 (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)
NOTCH1 PEST domain mutants bind DLL1 (Homo sapiens)
NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)
as an output of
Expression of DLL1 during nephron development (Homo sapiens)
DLL1 gene expression is inhibited by MECP2 (Homo sapiens)
Expression of DLL1 in paraxial mesoderm (Homo sapiens)
Expression of DLL1 in presomitic mesoderm (Homo sapiens)
as a member of
DLL/JAG [plasma membrane] (Homo sapiens)
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
as a protein marker of
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
Other forms of this molecule
Ub-DLL1 [plasma membrane]
Inferred To
DLL1 [plasma membrane]
(Bos taurus)
DLL1 [plasma membrane]
(Canis familiaris)
DLL1 [plasma membrane]
(Gallus gallus)
DLL1 [plasma membrane]
(Sus scrofa)
dla [plasma membrane]
(Danio rerio)
Delta [plasma membrane]
(Drosophila melanogaster)
Dll1 [plasma membrane]
(Mus musculus)
Dll1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_005609.3
ENSEMBL
ENSP00000355718
,
ENST00000616526
,
ENST00000366756
,
ENSP00000480905
OpenTargets
ENSG00000198719
HPA
ENSG00000198719-DLL1
PRO
O00548
Pharos - Targets
O00548
GlyGen
O00548
Orphanet
DLL1
PDB
4XBM
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