NOTCH1 HD domain mutants bind DLL1

Stable Identifier
R-HSA-2691219
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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DLL1 binds to NOTCH1 HD (heterodimerization) domain mutants, thereby activating them and stimulating signaling (Malecki et al. 2006).

Literature References
PubMed ID Title Journal Year
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Malecki, MJ, Sanchez-Irizarry, C, Mitchell, JL, Histen, G, Xu, ML, Aster, JC, Blacklow, SC

Mol. Cell. Biol. 2006
Participants
Participates
Normal reaction
Functional status

Gain of function of NOTCH1 HD domain mutants [plasma membrane]

Status
Disease
Name Identifier Synonyms
T-cell leukemia DOID:715
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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