NOTCH3 binds DLL1

Stable Identifier
R-HSA-157145
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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NOTCH3 binds DLL1
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Based on a study with mouse proteins, NOTCH3 receptor binds to DLL1 ligand (Shimizu et al. 2000). The interaction of DLL1 and NOTCH3 is implicated in functional differentiation of activated CD4+ T lymphocytes into type 1 helper T cells (Th1) (Maekawa et al. 2003). The effect of Fringe-mediated modification of NOTCH3 on its interaction with DLL1 is poorly studied (Hou et al. 2012).

Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Event Information
Go Biological Process
Notch signaling pathway (0007219)
Inferred From
Notch3 binds Dll1 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Jassal, B  (2004-12-15)
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