NOTCH3 binds DLL1

Stable Identifier
R-HSA-157145
Type
Reaction [binding]
Species
Homo sapiens
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Based on a study with mouse proteins, NOTCH3 receptor binds to DLL1 ligand (Shimizu et al. 2000). The interaction of DLL1 and NOTCH3 is implicated in functional differentiation of activated CD4+ T lymphocytes into type 1 helper T cells (Th1) (Maekawa et al. 2003). The effect of Fringe-mediated modification of NOTCH3 on its interaction with DLL1 is poorly studied (Hou et al. 2012).

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