DLL1 binds NOTCH2

Stable Identifier
R-HSA-1980048
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
4/5
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DLL1 binds NOTCH2
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DLL1, expressed on the surface of a neighboring cell, binds NOTCH2 and activates NOTCH2-mediated intracellular signaling (Shimizu et al. 2000). Modification of NOTCH2 extracellular domain by fringe enzymes enhances NOTCH2 activation by DLL1 (Hicks et al. 2000). Activation of NOTCH2 signaling by DLL1 may regulate regeneration and proliferation of renal tubules during acute kidney injury (Kobayashi et al. 2008).

NOTCHNLs, highly similar human-specific proteins encoded by Hominidae-specific NOTCH2NLA, NOTCH2NLB, and NOTCH2NLC genes that originate from the partial duplication of the NOTCH2 gene, stimulate NOTCH signaling (Fiddes et al. 2018, Suzuki et al. 2018) both in the presence and absence of the in trans DLL1 ligand (Fiddes et al. 2018). As a recombinant NOTCH2NLB was used in functional studies, NOTCH2NLB is annotated as a set member, while NOTCH2NLA and NOTCH2NLC are annotated as set candidates in this reaction describing the binding of DLL1 to NOTCH2. Although NOTCH1, NOTCH2, and NOTCH3 reporters were used to measure NOTCHNL-mediated activation of NOTCH signaling, the activity of NOTCH2NLs is only shown in the context of NOTCH2 signaling for several reasons. NOTCH2NLs are co-expressed with NOTCH2 due to promoter region of NOTCH2 being part of the duplicated segment (Fiddes et al. 2018, Suzuki et al. 2018), they likely act in cis, and are they are most similar in sequence to NOTCH2.

Literature References
PubMed ID Title Journal Year
10958687 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

Kanda, Y, Kurokawa, M, Shimizu, K, Hirai, H, Kumano, K, Hamada, Y, Saito, T, Chiba, S, Hosoya, N

Mol Cell Biol 2000
10934472 Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

Collazo, A, Johnston, SH, Hicks, C, Weinmaster, G, diSibio, G, Vogt, TF

Nat Cell Biol 2000
29856954 Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

Nuttle, X, Zwolinski, S, Haeussler, M, Rosenkrantz, JL, Pollen, AA, Eichler, EE, Russo, L, Mantalas, GL, Ewing, AD, Novak, AM, Kriegstein, A, Jacobs, FMJ, Katzman, S, Lodewijk, GA, Mooring, M, Bosworth, CM, Fiddes, IT, Addor, MC, van den Bout, A, Bishara, A, Field, AR, Bhaduri, A, Lorig-Roach, R, Haussler, D, Nowakowski, TJ, Dougherty, ML, Salama, SR

Cell 2018
1840698 A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

Miller, J, Abraham, JA, Fiddes, JC, Higashiyama, S, Klagsbrun, M

Science 1991
29856955 Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

Polleux, F, Detours, V, Herpoel, A, Vanderhaeghen, P, Wojno, M, Kumar, D, Lambert, N, Suzuki, IK, Bilheu, A, Gacquer, D, Van Heurck, R, Cheron, J

Cell 2018
18418349 Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury

Kuwana, H, Tanaka, H, Kuwahara, M, Tohda, S, Kobayashi, T, Sasaki, S, Okado, T, Sakano, S, Terada, Y

Kidney Int 2008
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region] (Homo sapiens)
Inferred From
Dll1 binds Notch2 (Mus musculus)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Ilagan, MXG  (2013-04-25)
Haw, R  (2013-01-14)
Boyle, S  (2013-04-25)
Created
Orlic-Milacic, M  (2011-11-09)
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