DLL1 binds NOTCH2

Stable Identifier
R-HSA-1980048
Type
Reaction [binding]
Species
Homo sapiens
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DLL1, expressed on the surface of a neighboring cell, binds NOTCH2 and activates NOTCH2-mediated intracellular signaling (Shimizu et al. 2000). Modification of NOTCH2 extracellular domain by fringe enzymes enhances NOTCH2 activation by DLL1 (Hicks et al. 2000). Activation of NOTCH2 signaling by DLL1 may regulate regeneration and proliferation of renal tubules during acute kidney injury (Kobayashi et al. 2008).

Literature References
PubMed ID Title Journal Year
10934472 Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

Hicks, C, Johnston, SH, diSibio, G, Collazo, A, Vogt, TF, Weinmaster, G

Nat Cell Biol 2000
10958687 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

Shimizu, K, Chiba, S, Hosoya, N, Kumano, K, Saito, T, Kurokawa, M, Kanda, Y, Hamada, Y, Hirai, H

Mol Cell Biol 2000
18418349 Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury

Kobayashi, T, Terada, Y, Kuwana, H, Tanaka, H, Okado, T, Kuwahara, M, Tohda, S, Sakano, S, Sasaki, S

Kidney Int 2008
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