DLL1, expressed on the surface of a neighboring cell, binds NOTCH2 and activates NOTCH2-mediated intracellular signaling (Shimizu et al. 2000). Modification of NOTCH2 extracellular domain by fringe enzymes enhances NOTCH2 activation by DLL1 (Hicks et al. 2000). Activation of NOTCH2 signaling by DLL1 may regulate regeneration and proliferation of renal tubules during acute kidney injury (Kobayashi et al. 2008).
Kanda, Y, Kurokawa, M, Shimizu, K, Hirai, H, Kumano, K, Hamada, Y, Saito, T, Chiba, S, Hosoya, N
Collazo, A, Johnston, SH, Hicks, C, Weinmaster, G, diSibio, G, Vogt, TF
Kuwana, H, Tanaka, H, Kuwahara, M, Tohda, S, Kobayashi, T, Sasaki, S, Okado, T, Sakano, S, Terada, Y
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