NOTCH1 PEST domain mutants bind DLL1

Stable Identifier
R-HSA-2769008
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH1 PEST domain mutants bind DLL1
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NOTCH1 PEST domain mutants are expected to bind to DLL1 ligand in an identical fashion to wild-type NOTCH1 (Jarriault et al. 1998, Yang et al. 2005, Cordle et al. 2008).
Literature References
PubMed ID Title Journal Year
18296446 Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity

Cordle, J, Redfield, C, Stacey, M, van der Merwe, PA, Willis, AC, Champion, BR, Hambleton, S, Handford, PA

J Biol Chem 2008
15574878 Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

Yang, LT, Nichols, JT, Yao, C, Manilay, JO, Robey, EA, Weinmaster, G

Mol Biol Cell 2005
9819428 Delta-1 activation of notch-1 signaling results in HES-1 transactivation

Jarriault, S, Le, Bail O, Hirsinger, E, Pourquie, O, Logeat, F, Strong, CF, Brou, C, Seidah, NG, Isra, l A

Mol Cell Biol 1998
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Normal reaction
NOTCH1 binds DLL1 (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST domain mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Cross References
Mondo
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-12-11)
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