NOTCH1 PEST domain mutants bind DLL1

Stable Identifier
Reaction [binding]
Homo sapiens
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NOTCH1 PEST domain mutants are expected to bind to DLL1 ligand in an identical fashion to wild-type NOTCH1 (Jarriault et al. 1998, Yang et al. 2005, Cordle et al. 2008).

Literature References
PubMed ID Title Journal Year
15574878 Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

Yang, LT, Nichols, JT, Yao, C, Manilay, JO, Robey, EA, Weinmaster, G

Mol Biol Cell 2005
18296446 Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity

Cordle, J, Redfield, C, Stacey, M, van der Merwe, PA, Willis, AC, Champion, BR, Hambleton, S, Handford, PA

J Biol Chem 2008
9819428 Delta-1 activation of notch-1 signaling results in HES-1 transactivation

Jarriault, S, Le, Bail O, Hirsinger, E, Pourquie, O, Logeat, F, Strong, CF, Brou, C, Seidah, NG, Isra, l A

Mol Cell Biol 1998
Participant Of
Normal reaction
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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