DLL1 gene expression is inhibited by MECP2

Stable Identifier
R-HSA-9023351
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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DLL1 gene expression is inhibited by MECP2
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Based on studies in mice, increased MECP2 occupancy of the DLL1 gene promoter, encoding NOTCH ligand Delta 1, correlates with decreased transcription of DLL1. MECP2 therefore inhibits DLL1 transcription (Li et al. 2014).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:DLL1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Inferred From
Dll1 gene expression is inhibited by Mecp2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-27)
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