NOTCH1 HD+PEST domain mutants bind DLL1

Stable Identifier
R-HSA-2900748
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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NOTCH1 in cis HD and PEST domain mutants are expected to bind DLL1 ligand, just like NOTCH1 HD mutants alone (Malecki et al. 2006).
Literature References
PubMed ID Title Journal Year
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Mitchell, JL, Malecki, MJ, Blacklow, SC, Xu, ML, Sanchez-Irizarry, C, Aster, JC, Histen, G

Mol. Cell. Biol. 2006
Participants
Participates
Normal reaction
Functional status

Gain of function of NOTCH1 HD+PEST Domain Mutants [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Reviewed
Created
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