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BID(62-195) [cytosol]
Stable Identifier
R-HSA-139953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
BID, tBID-p15
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation, myristolyation of BID and translocation to mitochondria (Homo sapiens)
Caspase-8 activates BID by cleavage (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
Granzyme-B activates BID by cleavage (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
Myristoylation of tBID by NMT1 (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
Activation, translocation and oligomerization of BAX (Homo sapiens)
tBID activates BAX protein (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
tBID bound to inactive BAX [cytosol] (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
tBID binds to inactive BAX protein (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
tBID bound to inactive BAX [cytosol] (Homo sapiens)
BID(62-195) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55957 BID
Gene Names
BID
Chain
chain:1-195, chain:61-195, chain:76-195, chain:100-195
Reference Genes
BioGPS Gene:637 BID
COSMIC (genes):BID BID
CTD Gene:637 BID
dbSNP Gene:637 BID
ENSEMBL:ENSG00000015475 BID
ENSEMBL_homo_sapiens_GENE:ENSG00000015475.19 BID
HGNC:1050 BID
KEGG Gene (Homo sapiens):637 BID
Monarch:637 BID
NCBI Gene:637 BID
OMIM:601997 BID
UCSC:P55957 BID
Reference Transcript
RefSeq:NM_001244569.1 BID
RefSeq:NM_197966.2 BID
RefSeq:NM_197967.2 BID
RefSeq:NM_001196.3 BID
RefSeq:NM_001244570.1 BID
RefSeq:NM_001244572.1 BID
RefSeq:NM_001244567.1 BID
Other Identifiers
11724046_a_at
11732217_a_at
11732218_x_at
11745421_a_at
16932008
204493_PM_at
204493_at
211725_PM_s_at
211725_s_at
227143_PM_s_at
227143_s_at
32725_at
32726_g_at
3951928
3951929
3951930
3951931
3951932
3951935
3951936
3951937
3951938
3951939
3951942
3951944
3951945
3951951
3951952
3951953
3951954
3951955
59612_at
59614_g_at
637
8074261
A_23_P154929
A_24_P187948
A_33_P3227041
GE54366
GO:0000278
GO:0001836
GO:0002376
GO:0005123
GO:0005515
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0006091
GO:0006626
GO:0006886
GO:0006915
GO:0006950
GO:0007005
GO:0008625
GO:0008637
GO:0010918
GO:0012501
GO:0016020
GO:0023052
GO:0031334
GO:0031625
GO:0031966
GO:0042129
GO:0042770
GO:0042775
GO:0042981
GO:0043028
GO:0043065
GO:0043226
GO:0050678
GO:0051402
GO:0061024
GO:0065003
GO:0090150
GO:0090200
GO:0097191
GO:0097284
GO:0097345
GO:0097435
GO:0098772
GO:1902108
GO:1902230
GO:2000045
GO:2000271
GO:2001233
GO:2001235
GO:2001238
GO:2001244
HMNXSV003050536
Hs.315689.1.A1_3p_at
ILMN_1763386
ILMN_2259495
ILMN_2372413
PH_hs_0029676
TC22000476.hg
g13543452_3p_s_at
g4557360_3p_at
Participates
as an input of
Myristoylation of tBID by NMT1 (Homo sapiens)
tBID binds to inactive BAX protein (Homo sapiens)
as an output of
Caspase-8 activates BID by cleavage (Homo sapiens)
Granzyme-B activates BID by cleavage (Homo sapiens)
tBID activates BAX protein (Homo sapiens)
as a component of
tBID bound to inactive BAX [cytosol] (Homo sapiens)
Other forms of this molecule
MYS-BID(62-195) [mitochondrial outer membrane]
MYS-BID(62-195) [cytosol]
BID(1-195) [cytosol]
Inferred To
Bid [cytosol]
(Mus musculus)
Bid [cytosol]
(Rattus norvegicus)
bida [cytosol]
(Danio rerio)
BID(62-195) [cytosol]
(Gallus gallus)
bid [cytosol]
(Xenopus tropicalis)
BID [cytosol]
(Bos taurus)
BID [cytosol]
(Canis familiaris)
BID [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001187.1
,
NP_932071.1
,
NP_932070.1
,
NP_001231501.1
,
NP_001231496.1
,
NP_001231499.1
,
NP_001231498.1
OpenTargets
ENSG00000015475
HPA
ENSG00000015475-BID
GeneCards
P55957
Ensembl
ENSG00000015475
,
ENST00000622694
,
ENST00000399767
,
ENST00000342111
,
ENST00000317361
,
ENSP00000382669
,
ENST00000399765
,
ENSP00000382667
,
ENSP00000449236
,
ENSP00000477773
,
ENSP00000318822
,
ENSP00000344594
,
ENSP00000480414
,
ENST00000551952
,
ENST00000614949
PRO
P55957
Pharos - Targets
P55957
PDB
2M5I
,
8SM5
,
5C3F
,
4ZEQ
,
7QTW
,
4ZII
,
1ZY3
,
4ZIG
,
2KBW
,
2M5B
,
7M5B
,
4BD2
,
4QVE
,
5AJJ
,
7P33
,
2BID
,
7M5A
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.869
9
UniProt:Q07817-1 BCL2L1
0.862
7
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.823
17
UniProt:Q92843 B2CL2
0.806
7
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.761
4
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.702
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.675
3
UniProt:Q07440 B2LA1
0.609
3
UniProt:P17361 PG035
0.589
2
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:O43865 AHCYL1
1
AHCYL1 [endoplasmic reticulum membrane]
(R-HSA-5215973)
0.556
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.524
2
UniProt:P97287 MCL1
0.499
3
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.463
3
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