Myristoylation of tBID by NMT1

Stable Identifier
R-HSA-141367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Myristoylation of tBID by NMT1
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After proteolytic activation, tBID is myristoylated by NMT-1 at an exposed glycine. N-myristoylation may enable the activated tBID to associate with the lipid components of the mitochondrial membrane.
Literature References
PubMed ID Title Journal Year
11099414 Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

Zha, J, Weiler, S, Oh, KJ, Wei, MC, Korsmeyer, SJ

Science 2000
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Catalyst Activity

myristoyltransferase activity of NMT 1 [cytosol]

Physical Entity
NMT1 [cytosol] (Homo sapiens)
Activity
myristoyltransferase activity (GO:0019107)
Orthologous Events
Myristoylation of tBID by NMT1 (Bos taurus)
Myristoylation of tBID by NMT1 (Canis familiaris)
Myristoylation of tBID by NMT1 (Danio rerio)
Myristoylation of tBID by NMT1 (Gallus gallus)
Myristoylation of tBID by NMT1 (Mus musculus)
Myristoylation of tBID by NMT1 (Rattus norvegicus)
Myristoylation of tBID by NMT1 (Sus scrofa)
Myristoylation of tBID by NMT1 (Xenopus tropicalis)
Authored
Gopinathrao, G  (2004-11-08)
Created
Gopinathrao, G  (2004-09-16)
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