Myristoylation of tBID by NMT1

Stable Identifier
R-HSA-141367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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After proteolytic activation, tBID is myristoylated by NMT-1 at an exposed glycine. N-myristoylation may enable the activated tBID to associate with the lipid components of the mitochondrial membrane.
Literature References
PubMed ID Title Journal Year
11099414 Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

Wei, MC, Zha, J, Oh, KJ, Korsmeyer, SJ, Weiler, S

Science 2000
Participants
Participates
Catalyst Activity

myristoyltransferase activity of NMT 1 [cytosol]

Orthologous Events
Authored
Created
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