Granzyme-B activates BID by cleavage

Stable Identifier
R-HSA-139893
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Granzyme-B activates BID by cleavage
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GZMB (granzyme B) cleaves BID to produce a p15 truncated form of BID (tBID) (Alimonti et al. 2001).
Literature References
PubMed ID Title Journal Year
11114298 Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

Alimonti, JB, Shi, L, Baijal, PK, Greenberg, AH

J Biol Chem 2001
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Catalyst Activity

serine-type endopeptidase activity of GZMB [cytosol]

Physical Entity
GZMB [cytosol] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Granzyme-B activates BID by cleavage (Bos taurus)
Granzyme-B activates BID by cleavage (Canis familiaris)
Granzyme-B activates BID by cleavage (Gallus gallus)
Granzyme-B activates BID by cleavage (Mus musculus)
Granzyme-B activates BID by cleavage (Rattus norvegicus)
Granzyme-B activates BID by cleavage (Sus scrofa)
Granzyme-B activates BID by cleavage (Xenopus tropicalis)
Created
Gopinathrao, G  (2004-08-09)
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