Caspase-8 activates BID by cleavage

Stable Identifier
R-HSA-139898
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Caspase-8 activates BID by cleavage
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The caspase 8 -mediated cleavage of cytosolic, inactive p22 BID at internal Asp sites yields a major p15 and minor p13 and p11 fragments. After myristoylation, tBID translocates to mitochondria as an integral membrane protein.

Literature References
PubMed ID Title Journal Year
12804595 Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis

Gueulette, J, Denis, JM, Bischoff, P, Coelho, D, Fischer, B, Bergerat, JP, Dufour, P

Biochem Biophys Res Commun 2003
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-8 [cytosol]

Physical Entity
active caspase-8 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-8 activates BID by cleavage (Bos taurus)
Caspase-8 activates BID by cleavage (Canis familiaris)
Caspase-8 activates BID by cleavage (Danio rerio)
Caspase-8 activates BID by cleavage (Gallus gallus)
Caspase-8 activates BID by cleavage (Mus musculus)
Caspase-8 activates BID by cleavage (Rattus norvegicus)
Caspase-8 activates BID by cleavage (Sus scrofa)
Caspase-8 activates BID by cleavage (Xenopus tropicalis)
Authored
Gopinathrao, G  (2005-04-27)
Created
Gopinathrao, G  (2004-08-09)
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