tBID activates BAX protein

Stable Identifier
R-HSA-139917
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
tBID activates BAX protein
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

During certain types of apoptosis, activated tBID (p15) induces a change in conformation of Bax which leads to the unmasking of its NH2-terminal domain. This change in confirmation usually results in the release of cytochrome c from mitochondria.

Literature References
PubMed ID Title Journal Year
10629050 Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

Eskes, R, Desagher, S, Antonsson, B, Martinou, JC

Mol Cell Biol 2000
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
tBID activates BAX protein (Bos taurus)
tBID activates BAX protein (Canis familiaris)
tBID activates BAX protein (Danio rerio)
tBID activates BAX protein (Mus musculus)
tBID activates BAX protein (Rattus norvegicus)
tBID activates BAX protein (Sus scrofa)
tBID activates BAX protein (Xenopus tropicalis)
Authored
Gopinathrao, G  (2005-04-27)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)