tBID activates BAX protein

Stable Identifier
R-HSA-139917
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
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tBID activates BAX protein
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During certain types of apoptosis, activated tBID (p15) induces a change in conformation of Bax which leads to the unmasking of its NH2-terminal domain. This change in confirmation usually results in the release of cytochrome c from mitochondria.

Literature References
PubMed ID Title Journal Year
10629050 Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

Eskes, R, Desagher, S, Antonsson, B, Martinou, JC

Mol Cell Biol 2000
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Orthologous Events
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tBID activates BAX protein (Xenopus tropicalis)
Authored
Gopinathrao, G  (2005-04-27)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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