Reactome | Spry regulation of FGF signaling

Spry regulation of FGF signaling

Stable Identifier

R-HSA-1295596

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Sprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most widely expressed. Spry proteins modulate the duration and extent of signaling through the MAPK cascade after FGF stimulation, although the mechanism appears to depend on the particular biological context. Some studies have suggested that Sprouty binds to GRB2 and interferes with the recruitment of GRB2-SOS1 to the receptor, while others have shown that Sprouty interferes with the MAPK cascade at the level of RAF activation. In addition to modulating the MAPK pathway in response to FGF stimulation, Sprouty itself appears to be subject to complex post-translational modification that regulates its activity and stability.

Literature References

PubMed ID	Title	Journal	Year
19690147	Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation Brady, SC, Coleman, ML, Munro, J, Feller, SM, Morrice, NA, Olson, MF	Cancer Res	2009
19570949	Intermolecular interactions of Sprouty proteins and their implications in development and disease Edwin, F, Anderson, K, Ying, C, Patel, TB	Mol Pharmacol	2009
9458049	sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways Hacohen, N, Kramer, S, Sutherland, D, Hiromi, Y, Krasnow, MA	Cell	1998
16893902	A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation Lao, DH, Chandramouli, S, Yusoff, P, Fong, CW, Saw, TY, Tai, LP, Yu, CY, Leong, HF, Guy, GR	J Biol Chem	2006