In humans, the phosphorylated adaptor protein Sprouty2 is ubiquitinated by the E3 ubiquitin ligase CBL, marking it for degradation by the 26S proteasome.
Hall, AB, Jura, N, Gong, D, DaSilva, J, Bar-Sagi, D, Jang, YJ
Gross, I, Mason, JM, Dimri, M, Licht, JD, Band, H, Morrison, DJ, Bassit, B
Litvak, V, Lev, S, Zwang, Y, Yarden, Y, Medvedovsky, H, Rubin, C
ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]
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