Reactome | Phosphorylated SPRY2 is ubiquitinated by CBL

Phosphorylated SPRY2 is ubiquitinated by CBL

Stable Identifier

R-HSA-934604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Phosphorylated SPRY2 is ubiquitinated by CBL

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In humans, the phosphorylated adaptor protein Sprouty2 is ubiquitinated by the E3 ubiquitin ligase CBL, marking it for degradation by the 26S proteasome.

Literature References

PubMed ID	Title	Journal	Year
15004239	Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop Mason, JM, Morrison, DJ, Bassit, B, Dimri, M, Band, H, Licht, JD, Gross, I	Mol Biol Cell	2004
12593796	hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl Hall, AB, Jura, N, DaSilva, J, Jang, YJ, Gong, D, Bar-Sagi, D	Curr Biol	2003
12593795	Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops Rubin, C, Litvak, V, Medvedovsky, H, Zwang, Y, Lev, S, Yarden, Y	Curr Biol	2003