Phosphorylated SPRY2 is ubiquitinated by CBL

Stable Identifier
R-HSA-934604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In humans, the phosphorylated adaptor protein Sprouty2 is ubiquitinated by the E3 ubiquitin ligase CBL, marking it for degradation by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
15004239 Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop

Mason, JM, Morrison, DJ, Bassit, B, Dimri, M, Band, H, Licht, JD, Gross, I

Mol Biol Cell 2004
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, DaSilva, J, Jang, YJ, Gong, D, Bar-Sagi, D

Curr Biol 2003
12593795 Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

Rubin, C, Litvak, V, Medvedovsky, H, Zwang, Y, Lev, S, Yarden, Y

Curr Biol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created