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B-RAF dissociates from S111/S120 p-SPRY2
Stable Identifier
R-HSA-1295604
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)
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MAPK-dependent serine phosphorylation of SPRY2 disrupts complex formation with B-RAF.
Literature References
PubMed ID
Title
Journal
Year
19690147
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation
Brady, SC
,
Coleman, ML
,
Olson, MF
,
Feller, SM
,
Munro, J
,
Morrice, NA
Cancer Res
2009
Participants
Input
S111/S120 p-SPRY2:B-RAF [cytosol]
(Homo sapiens)
Output
BRAF [cytosol]
(Homo sapiens)
p-S111,S120-SPRY2 [cytosol]
(Homo sapiens)
Participates
as an event of
Spry regulation of FGF signaling (Homo sapiens)
Orthologous Events
B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)
B-RAF dissociates from S111/S120 p-SPRY2 (Canis familiaris)
B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)
B-RAF dissociates from S111/S120 p-SPRY2 (Gallus gallus)
B-RAF dissociates from S111/S120 p-SPRY2 (Mus musculus)
B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)
B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)
Authored
Rothfels, K (2011-08-15)
Reviewed
Gotoh, N (2011-08-26)
Created
Rothfels, K (2011-05-18)
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