PPTN11 (also known as SHP2) may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling.
Yasunaga, T, Hanafusa, H, Nishida, E, Matsumoto, K, Torii, S
Salles, JP, Raynal, P, Dance, M, Yart, A, Montagner, A
protein tyrosine phosphatase activity of PTPN11 [cytosol]
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