PPTN11 dephosphorylates SPRY2

Stable Identifier
R-HSA-1549564
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Summation

PPTN11 (also known as SHP2) may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling.

Literature References
PubMed ID Title Journal Year
17993263 The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

Dance, M, Montagner, A, Salles, JP, Yart, A, Raynal, P

Cell Signal 2008
15031289 Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

Hanafusa, H, Torii, S, Yasunaga, T, Matsumoto, K, Nishida, E

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN11 [cytosol]
Physical Entity
PTPN11 [cytosol]
Activity
protein tyrosine phosphatase activity (0004725)
Orthologous Events
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Drosophila melanogaster)
PPTN11 dephosphorylates SPRY2 (Gallus gallus)
PPTN11 dephosphorylates SPRY2 (Mus musculus)
PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Taeniopygia guttata)
PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)