PPTN11 dephosphorylates SPRY2

Stable Identifier
R-HSA-1549564
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PPTN11 (also known as SHP2) may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN11 [cytosol]
Physical Entity
Activity
Orthologous Events