PPTN11 dephosphorylates SPRY2

Stable Identifier
R-HSA-1549564
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PPTN11 dephosphorylates SPRY2
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PPTN11 (also known as SHP2) may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling.
Literature References
PubMed ID Title Journal Year
15031289 Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

Hanafusa, H, Torii, S, Yasunaga, T, Matsumoto, K, Nishida, E

J Biol Chem 2004
17993263 The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

Dance, M, Montagner, A, Salles, JP, Yart, A, Raynal, P

Cell Signal 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN11 [cytosol]

Physical Entity
PTPN11 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Mus musculus)
PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2011-08-30)
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