Reactome | PPTN11 dephosphorylates SPRY2

PPTN11 dephosphorylates SPRY2

Stable Identifier

R-HSA-1549564

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - Negative regulation of FGFR1 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Negative regulation of FGFR2 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
    - Signaling by FGFR3 (Homo sapiens)
      - Negative regulation of FGFR3 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Negative regulation of FGFR4 signaling (Homo sapiens)
        
        Spry regulation of FGF signaling (Homo sapiens)
        
        PPTN11 dephosphorylates SPRY2 (Homo sapiens)

Summation

PPTN11 (also known as SHP2) may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling.

Literature References

PubMed ID	Title	Journal	Year
17993263	The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway	Cell Signal	2008
15031289	Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty	J Biol Chem	2004