Negative regulation of FGFR3 signaling

Stable Identifier
Homo sapiens
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Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway.

Literature References
PubMed ID Title Journal Year
12815057 Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

Fong, CW, Leong, HF, Wong, ES, Lim, J, Yusoff, P, Guy, GR

J Biol Chem 2003
20940169 Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

Itoh, N, Ornitz, DM

J Biochem 2011
11997436 FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl

Wong, A, Lamothe, B, Lee, A, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2002
18452557 Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

Gotoh, N

Cancer Sci 2008
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