SRC phosphorylates SPRY2 on Y55 and Y227

Stable Identifier
R-HSA-1295609
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Sprouty 2 protein is phosphorylated on tyrosine residue 55. The ability of SRC kinase to catalyze this reaction has been demonstrated with purified proteins in vitro (Li et al. 2004) and in cultured cells with studies of the effects of SRC-family pharmacological inhibitors and of dominant-negative mutant SRC proteins (Mason et al. 2004). SRC kinase also phosphorylates numerous tyrosine residues in the C terminal region of SPRY2 including Y227, in response to FGF but not EGF stimulation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [plasma membrane]
Physical Entity
Activity
This entity is regulated by
Orthologous Events