SPRY2 translocates to the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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SPRY2 translocates to the plasma membrane upon activation of cells with FGF, and translocation is required for the inhibition of growth factor-stimulated cell migration, proliferation and differentiation. Translocation may be mediated by interactions with PIP2 in the membrane, palmitoylation of the C-terminal region of SPRY2 and/or interactions with caveolin-1.

Literature References
PubMed ID Title Journal Year
11238463 Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

Impagnatiello, MA, Weitzer, S, Gannon, G, Compagni, A, Cotten, M, Christofori, G

J Cell Biol 2001
12391162 The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes

Lim, J, Yusoff, P, Wong, ES, Chandramouli, S, Lao, DH, Fong, CW, Guy, GR

Mol Cell Biol 2002
10887178 Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain

Lim, J, Wong, ES, Ong, SH, Yusoff, P, Low, BC, Guy, GR

J Biol Chem 2000
11279012 The C terminus of sprouty is important for modulation of cellular migration and proliferation

Yigzaw, Y, Cartin, L, Pierre, S, Scholich, K, Patel, TB

J Biol Chem 2001
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