SPRY2 translocates to the plasma membrane upon activation of cells with FGF, and translocation is required for the inhibition of growth factor-stimulated cell migration, proliferation and differentiation. Translocation may be mediated by interactions with PIP2 in the membrane, palmitoylation of the C-terminal region of SPRY2 and/or interactions with caveolin-1.
Lao, DH, Yusoff, P, Fong, CW, Chandramouli, S, Wong, ES, Lim, J, Guy, GR
Gannon, G, Impagnatiello, MA, Cotten, M, Christofori, G, Compagni, A, Weitzer, S
Yusoff, P, Low, BC, Ong, SH, Wong, ES, Lim, J, Guy, GR
Scholich, K, Pierre, S, Yigzaw, Y, Patel, TB, Cartin, L
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