SPRY2 translocates to the plasma membrane

Stable Identifier
R-HSA-1295599
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SPRY2 translocates to the plasma membrane
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SPRY2 translocates to the plasma membrane upon activation of cells with FGF, and translocation is required for the inhibition of growth factor-stimulated cell migration, proliferation and differentiation. Translocation may be mediated by interactions with PIP2 in the membrane, palmitoylation of the C-terminal region of SPRY2 and/or interactions with caveolin-1.
Literature References
PubMed ID Title Journal Year
12391162 The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes

Lim, J, Yusoff, P, Wong, ES, Chandramouli, S, Lao, DH, Fong, CW, Guy, GR

Mol Cell Biol 2002
11238463 Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

Impagnatiello, MA, Weitzer, S, Gannon, G, Compagni, A, Cotten, M, Christofori, G

J Cell Biol 2001
10887178 Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain

Lim, J, Wong, ES, Ong, SH, Yusoff, P, Low, BC, Guy, GR

J Biol Chem 2000
11279012 The C terminus of sprouty is important for modulation of cellular migration and proliferation

Yigzaw, Y, Cartin, L, Pierre, S, Scholich, K, Patel, TB

J Biol Chem 2001
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Orthologous Events
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SPRY2 translocates to the plasma membrane (Drosophila melanogaster)
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SPRY2 translocates to the plasma membrane (Rattus norvegicus)
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SPRY2 translocates to the plasma membrane (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2011-05-18)
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