The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation.
Hall, AB, Jura, N, Gong, D, DaSilva, J, Bar-Sagi, D, Jang, YJ
Low, BC, Wong, ES, Chen, Q, Lim, J, Guy, GR
Yusoff, P, Fong, CW, Wong, ES, Lim, J, Leong, HF, Guy, GR
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