SPRY2 binds CBL

Stable Identifier
R-HSA-1295622
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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SPRY2 binds CBL
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The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation.

Literature References
PubMed ID Title Journal Year
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, Gong, D, DaSilva, J, Bar-Sagi, D, Jang, YJ

Curr Biol 2003
11053437 Evidence for direct interaction between Sprouty and Cbl

Low, BC, Wong, ES, Chen, Q, Lim, J, Guy, GR

J Biol Chem 2001
12815057 Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

Yusoff, P, Fong, CW, Wong, ES, Lim, J, Leong, HF, Guy, GR

J Biol Chem 2003
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Orthologous Events
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SPRY2 binds CBL (Mus musculus)
SPRY2 binds CBL (Rattus norvegicus)
SPRY2 binds CBL (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2011-05-17)
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