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IN (Integrase) (P04585) protein [nucleoplasm]
Stable Identifier
R-HIV-175288
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
GO Cellular Component
host cell nucleoplasm
(0044095)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
1-LTR circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
2-LTR circle formation (Homo sapiens)
2-LTR formation due to circularization of viral DNA (Homo sapiens)
viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] (Homo sapiens)
Ku proteins bound to viral DNA [nucleoplasm] (Homo sapiens)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Association of XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)
Ku proteins bound to viral DNA [nucleoplasm] (Homo sapiens)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] (Homo sapiens)
Ku proteins bound to viral DNA [nucleoplasm] (Homo sapiens)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Association of Ku heterodimer with viral DNA ends (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Ku proteins bound to viral DNA [nucleoplasm] (Homo sapiens)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Autointegration results in viral DNA circles (Homo sapiens)
Suicidal integration leading to inverted circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Import of PIC to the Host Nucleus (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Integration of viral DNA into host genomic DNA (Homo sapiens)
Gap repair completes provirus integration (Homo sapiens)
Integration intermediate [nucleoplasm] (Homo sapiens)
IN:viral DNA bound to host genomic DNA [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Target DNA binding (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN:viral DNA bound to host genomic DNA with staggered ends [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Transesterification to connect viral DNA 3' ends to host DNA 5' ends (Homo sapiens)
IN:viral DNA bound to host genomic DNA with staggered ends [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Integration intermediate [nucleoplasm] (Homo sapiens)
IN:viral DNA bound to host genomic DNA [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
IN (Integrase) (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04585 gag-pol
Gene Names
gag-pol
Chain
initiator methionine:1, chain:2-1435, chain:2-132, chain:133-363, peptide:364-377, chain:378-432, peptide:433-440, chain:441-488, chain:489-587, chain:588-1147, chain:588-1027, chain:1028-1147, chain:1148-1435
Reference Genes
BioGPS Gene:155348 gag-pol
KEGG Gene (Viruses):155348 gag-pol
Monarch:155348 gag-pol
NCBI Gene:155348 gag-pol
Reference Transcript
RefSeq:NC_001802.1 gag-pol
Participant Of
output
1-LTR circle formation
2-LTR formation due to circularization of viral DNA
Gap repair completes provirus integration
Suicidal integration leading to inverted circle formation
Suicidal integration leading to smaller circles of viral DNA
hasComponent
IN bound to sticky 3' ends of viral DNA [nucleoplasm]
Ku proteins bound to viral DNA [nucleoplasm]
Other forms of this molecule
GAG-POL Polyprotein (P04585) [extracellular region]
GAG-POL Polyprotein (P04585) [plasma membrane]
MA (P04585) protein [nucleoplasm]
p6 (P04585) [nucleoplasm]
NC (P04585) protein [cytosol]
p6 (P04585) protein [cytosol]
CA (P04585) protein [cytosol]
Reverse transcriptase/ribonuclease H [cytosol]
p51 (RT) [cytosol]
PR (Protease) (P04585) protein [cytosol]
IN (Integrase) (P04585) protein [cytosol]
MA (P04585) protein [cytosol]
p6 (P04585) protein [extracellular region]
p51 (RT) [extracellular region]
Reverse transcriptase/ribonuclease H [extracellular region]
CA (P04585) protein [extracellular region]
PR (Protease) (P04585) protein [extracellular region]
IN (Integrase) (P04585) protein [extracellular region]
MA (P04585) protein [extracellular region]
NC (P04585) protein [extracellular region]
Cross References
RefSeq
NP_057849.4
IntEnz
3.4.23.16
PRO
P04585
PDB
3M8P
,
1KLM
,
1RT6
,
3KT2
,
5HRR
,
1ODW
,
6EWA
,
3DRS
,
2RF2
,
1RTI
,
1C1C
,
1FKO
,
1G6L
,
6DJ5
,
1A30
,
1DTT
,
5J2Q
,
2YNF
,
1BWA
,
1S1U
,
3T1A
,
1HVR
,
4NCG
,
5HRP
,
3DRR
,
3MEG
,
3LAN
,
4B3Q
,
1JLB
,
1HWR
,
3QIP
,
1TKT
,
2OPS
,
6UK0
,
4U1J
,
5YRS
,
1JLF
,
6DJ2
,
3T19
,
1JLG
,
2KOD
,
5J2P
,
1LWF
,
3DOX
,
1FK9
,
3DLE
,
3I0S
,
3AO2
,
1RT7
,
4KV8
,
6UIS
,
3LP1
,
6BSH
,
1LW0
,
1QBR
,
1BVG
,
6J1V
,
1LW2
,
2NPH
,
5T82
,
1RTJ
,
3KK1
,
1TAM
,
3C6U
,
1LV1
,
2HNY
,
3N3I
,
1DMP
,
1LWE
,
2YNH
,
6GL1
,
1S1V
,
6OR7
,
3I0R
,
3KT5
,
1HVH
,
6UIR
,
5HRS
,
5EU7
,
1DTQ
,
2HND
,
6BSG
,
3M8Q
,
3LP0
,
6OTZ
,
1QBT
,
1JLE
,
3C6T
,
6DJ7
,
6EX9
,
1TKX
,
3KJV
,
2YNG
,
3TAM
,
1T05
,
1VRT
,
3MEC
,
1ESK
,
3DM2
,
1ODY
,
3E01
,
1RTD
,
6P1I
,
3LAK
,
1E6J
,
1FB7
,
2WON
,
6BSJ
,
6DV0
,
6BJ2
,
6DIF
,
1QBU
,
1BV9
,
1TL1
,
2OPP
,
4Q1W
,
3KK3
,
6UJX
,
6PYL
,
1S1W
,
3NBP
,
5KAO
,
1EX4
,
1JLQ
,
3DLG
,
1C0U
,
6BSI
,
3LP2
,
3PHV
,
2WOM
,
6J1W
,
3DI6
,
1BVE
,
6UIT
,
1EXQ
,
3FFI
,
1C1B
,
2HNZ
,
3KK2
,
4QLH
,
1RT1
,
1TKZ
,
2YNI
,
4KSE
,
1RT3
,
5K14
,
5HRN
,
1RT5
,
1REV
,
2RKI
,
1HXB
,
5XOT
,
3DRP
,
3LAM
,
4B3P
,
3MEE
,
1QBS
,
1FKP
,
1NCP
,
1RTH
,
3DYA
,
5IM7
,
6DJ1
,
3QIO
,
6E9A
,
2OPR
,
5J2N
,
3DOL
,
4U1I
,
1BWB
,
1S1T
,
2WHH
,
5DGW
,
4U7V
,
1RT2
,
6P2G
,
4Q1Y
,
5TC2
,
6UJZ
,
6E7J
,
1EP4
,
1JLA
,
5VZ6
,
1VRU
,
5XOS
,
1C0T
,
4B3O
,
1HIV
,
4I7F
,
1JKH
,
3MED
,
3LAL
,
6BJ3
,
1JLC
,
2OPQ
,
6P1X
,
6DV4
,
3QIN
,
1BV7
,
4Q5M
,
6DIL
,
1TL3
,
5J2M
,
3DOK
,
3DMJ
,
1LWC
,
4U7Q
,
4U1H
,
6UJY
,
4Q1X
,
5DGU
,
1O1W
,
1RT4
,
1S1X
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04585 gag-pol
21
GAG-POL Polyprotein (P04585) [plasma membrane]
(R-HIV-3076336)
GAG-POL Polyprotein (P04585) [extracellular region]
(R-HIV-3139031)
MA (P04585) protein [nucleoplasm]
(R-HIV-3006250)
IN (Integrase) (P04585) protein [nucleoplasm]
(R-HIV-175288)
p6 (P04585) [nucleoplasm]
(R-HIV-175300)
NC (P04585) protein [cytosol]
(R-HIV-3006251)
p6 (P04585) protein [cytosol]
(R-HIV-3072746)
CA (P04585) protein [cytosol]
(R-HIV-3006247)
Reverse transcriptase/ribonuclease H [cytosol]
(R-HIV-173370)
p51 (RT) [cytosol]
(R-HIV-173834)
PR (Protease) (P04585) protein [cytosol]
(R-HIV-175182)
IN (Integrase) (P04585) protein [cytosol]
(R-HIV-173387)
MA (P04585) protein [cytosol]
(R-HIV-3006252)
p6 (P04585) protein [extracellular region]
(R-HIV-175560)
p51 (RT) [extracellular region]
(R-HIV-175342)
Reverse transcriptase/ribonuclease H [extracellular region]
(R-HIV-175316)
CA (P04585) protein [extracellular region]
(R-HIV-175492)
PR (Protease) (P04585) protein [extracellular region]
(R-HIV-173391)
IN (Integrase) (P04585) protein [extracellular region]
(R-HIV-175406)
MA (P04585) protein [extracellular region]
(R-HIV-175359)
NC (P04585) protein [extracellular region]
(R-HIV-3006248)
0.73
29
UniProt:P03366 POL
0.623
2
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