1-LTR circle formation

Stable Identifier
Reaction [dissociation]
Homo sapiens
Related Species
Human immunodeficiency virus 1
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The 1-LTR circle can be formed by either of two pathways. The first involves a failure to complete reverse transcription; the second, annotated here, follows the completion of reverse transcription and is mediated by cellular enzymes. In this pathway, the action of host cell homologous recombination enzymes on the long terminal repeat (LTR) termini of the viral DNA results in formation of a single LTR. This reaction probably takes place after partial or complete disassembly of the PIC to expose the viral DNA. Repair of this intermediate as in the late stages of homologous recombination pathways results in formation of the 1-LTR circle. Mutations in the Mre11/Rad50/NBS pathway influence the formation of 1-LTR circles.

Literature References
PubMed ID Title Journal Year
16175173 Genome-wide analysis of retroviral DNA integration

Lewinski, M, Ciuffi, A, Barr, S, Leipzig, J, Hannenhalli, S, Hoffmann, C, Bushman, FD

Nat Rev Microbiol 2005
16291214 Retroviral DNA integration--mechanism and consequences

Lewinski, MK, Bushman, FD

Adv Genet 2005

Coffin, JM, Hughes, SH, Varmus, HE

Participant Of
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
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