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IN (Integrase) (P04585) protein [extracellular region]
Stable Identifier
R-HIV-175406
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
extracellular region
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Conformational change in gp120 of Env oligomer (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Conformational changes in gp120 exposes gp41 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Fusogenic activation of gp41 (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
Maturation of HIV Virion (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
IN (Integrase) (P04585) protein [extracellular region] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04585 gag-pol
Gene Names
gag-pol
Chain
initiator methionine:, chain:2-1435, chain:2-132, chain:133-363, peptide:364-377, chain:378-432, peptide:433-440, chain:441-488, chain:489-587, chain:588-1147, chain:588-1027, chain:1028-1147, chain:1148-1435
Reference Genes
BioGPS Gene:155348 gag-pol
KEGG:vg:155348 gag-pol
Monarch:155348 gag-pol
NCBI Gene:155348 gag-pol
UCSC:P04585 gag-pol
Reference Transcript
RefSeq:NC_001802.1 env
Participates
as a component of
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
Other forms of this molecule
MA (P04585) protein [cytosol]
p6 (P04585) protein [cytosol]
IN (Integrase) (P04585) protein [cytosol]
p51 (RT) [cytosol]
Reverse transcriptase/ribonuclease H [cytosol]
NC (P04585) protein [extracellular region]
MA (P04585) protein [extracellular region]
PR (Protease) (P04585) protein [extracellular region]
CA (P04585) protein [extracellular region]
Reverse transcriptase/ribonuclease H [extracellular region]
p51 (RT) [extracellular region]
p6 (P04585) protein [extracellular region]
PR (Protease) (P04585) protein [cytosol]
CA (P04585) protein [cytosol]
NC (P04585) protein [cytosol]
p6 (P04585) [nucleoplasm]
IN (Integrase) (P04585) protein [nucleoplasm]
MA (P04585) protein [nucleoplasm]
GAG-POL Polyprotein (P04585) [plasma membrane]
GAG-POL Polyprotein (P04585) [extracellular region]
Cross References
IntEnz
3.4.23.16
PRO
P04585
PDB
1C1B
,
1BVE
,
3DOK
,
1ESK
,
5XOS
,
1EX4
,
5HRN
,
1LW0
,
5J2M
,
2WHH
,
3C6T
,
3DLG
,
6SKM
,
4Q1X
,
6UIR
,
1TL3
,
6UJX
,
3DRS
,
7SLS
,
1QBU
,
4U1H
,
1TKX
,
1RTI
,
2YNG
,
1JLC
,
6SKN
,
3M8P
,
3AO2
,
5IM7
,
2WOM
,
1G6L
,
6P1X
,
3DOL
,
6J1V
,
6VQ2
,
5EU7
,
7DT9
,
2KOD
,
3KT5
,
8TCL
,
3QIP
,
5J2N
,
5HRP
,
3C6U
,
2YNF
,
1JKH
,
8JYH
,
6BSH
,
1JLQ
,
3MEG
,
3PHV
,
1C0U
,
1A30
,
6DJ1
,
7SLR
,
2YNH
,
6WPH
,
1TL1
,
1RTH
,
1BWB
,
1RT5
,
3M8Q
,
3I0R
,
7R7X
,
2WON
,
1KLM
,
7XJ4
,
4U7V
,
8ERX
,
7XIU
,
1T05
,
4QLH
,
6E7J
,
1LV1
,
3KK1
,
6VPZ
,
8TCK
,
8ESX
,
1TAM
,
1RT2
,
6SKK
,
2NPH
,
4Q1W
,
6BSG
,
5DGW
,
6UIT
,
6BJ3
,
1BV7
,
6SLQ
,
3FFI
,
6DJ7
,
2HND
,
3TAM
,
3MED
,
2YNI
,
1EP4
,
1BWA
,
4B3Q
,
6DV0
,
1DMP
,
6VQY
,
4Q5M
,
5T82
,
3LP0
,
3DYA
,
7XJ5
,
5YRS
,
6OTZ
,
3KK2
,
3KJV
,
4KSE
,
8F7M
,
1EXQ
,
3N3I
,
4U7Q
,
6VQE
,
1RT1
,
8JYJ
,
5DGU
,
6BJ2
,
6DJ2
,
1C0T
,
1QBT
,
3LAK
,
1FK9
,
4U1I
,
6WB1
,
4B3P
,
1RT4
,
1RTD
,
3I0S
,
5XOT
,
1HXB
,
6VQZ
,
1S1X
,
3DOX
,
8FCD
,
3KK3
,
1BVG
,
1HVR
,
2RKI
,
8TCM
,
8ESY
,
1S1V
,
1FKP
,
8JYI
,
2OPS
,
6BSJ
,
6SMU
,
1ODY
,
1VRU
,
6UJZ
,
4NCG
,
3MEE
,
1QBS
,
3LAL
,
4I7F
,
4KV8
,
1JLB
,
3T19
,
4B3O
,
6WAZ
,
3DI6
,
1E6J
,
6DV4
,
3LP1
,
6GL1
,
2HNZ
,
3KT2
,
6PYL
,
1S1U
,
5HRR
,
3DM2
,
3DMJ
,
3QIN
,
1FKO
,
6EWA
,
1HWR
,
1LWF
,
5TC2
,
3LAM
,
1QBR
,
4U1J
,
1JLG
,
6DIF
,
2OPR
,
1RT3
,
6DIL
,
7R7V
,
1DTT
,
3LP2
,
1O1W
,
5VZ6
,
3E01
,
8FCC
,
1S1W
,
2HNY
,
1FB7
,
3NBP
,
5HRS
,
8F5A
,
6VQD
,
6BSI
,
5J2Q
,
1ODW
,
8F0F
,
3DLE
,
1LWE
,
3DRP
,
7DPQ
,
6WPJ
,
6UK0
,
6P1I
,
1JLA
,
1TKZ
,
1LWC
,
1JLF
,
1RTJ
,
2OPQ
,
3DRR
,
1RT7
,
6P2G
,
1REV
,
7DOZ
,
1DTQ
,
8FCE
,
6J1W
,
7XJ7
,
1C1C
,
5KAO
,
8TCJ
,
1S1T
,
1HVH
,
6E9A
,
3QIO
,
1LW2
,
5J2P
,
6WPF
,
3LAN
,
4Q1Y
,
6UJY
,
1VRT
,
5K14
,
1HIV
,
1TKT
,
6UIS
,
1BV9
,
1JLE
,
1NCP
,
6SLU
,
3MEC
,
2OPP
,
6OR7
,
6DJ5
,
3T1A
,
1RT6
,
7R80
,
2RF2
,
6EX9
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04585 gag-pol
20
MA (P04585) protein [cytosol]
(R-HIV-3006252)
p6 (P04585) protein [cytosol]
(R-HIV-3072746)
IN (Integrase) (P04585) protein [cytosol]
(R-HIV-173387)
p51 (RT) [cytosol]
(R-HIV-173834)
Reverse transcriptase/ribonuclease H [cytosol]
(R-HIV-173370)
NC (P04585) protein [extracellular region]
(R-HIV-3006248)
MA (P04585) protein [extracellular region]
(R-HIV-175359)
IN (Integrase) (P04585) protein [extracellular region]
(R-HIV-175406)
PR (Protease) (P04585) protein [extracellular region]
(R-HIV-173391)
CA (P04585) protein [extracellular region]
(R-HIV-175492)
Reverse transcriptase/ribonuclease H [extracellular region]
(R-HIV-175316)
p51 (RT) [extracellular region]
(R-HIV-175342)
p6 (P04585) protein [extracellular region]
(R-HIV-175560)
PR (Protease) (P04585) protein [cytosol]
(R-HIV-175182)
CA (P04585) protein [cytosol]
(R-HIV-3006247)
NC (P04585) protein [cytosol]
(R-HIV-3006251)
p6 (P04585) [nucleoplasm]
(R-HIV-175300)
IN (Integrase) (P04585) protein [nucleoplasm]
(R-HIV-175288)
MA (P04585) protein [nucleoplasm]
(R-HIV-3006250)
GAG-POL Polyprotein (P04585) [plasma membrane]
(R-HIV-3076336)
0.73
29
UniProt:P03366 POL
0.623
2
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