2-LTR formation due to circularization of viral DNA

Stable Identifier
R-HSA-175258
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
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2-LTR formation due to circularization of viral DNA
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Viral DNA that does not become integrated can undergo another fate, which is to have the two viral DNA ends joined together to form a 2-LTR circle. This reaction requires Ku, XRCC4 and ligase 4.

Literature References
PubMed ID Title Journal Year
  Retroviruses

Coffin, JM, Hughes, SH, Varmus, HE

  1997
16291214 Retroviral DNA integration--mechanism and consequences

Lewinski, MK, Bushman, FD

Adv Genet 2005
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Output
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Catalyst Activity

DNA ligase activity of viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm]

Physical Entity
viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] (Homo sapiens)
Activity
DNA ligase activity (GO:0003909)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gopinathrao, G  (2006-05-19)
D'Eustachio, P  (2006-05-19)
Reviewed
Bushman, FD  (2006-10-31)
Created
Gopinathrao, G  (2006-02-24)
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