Reactome | 2-LTR formation due to circularization of viral DNA

2-LTR formation due to circularization of viral DNA

Stable Identifier

R-HSA-175258

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Integration of provirus (Homo sapiens)
        
        2-LTR circle formation (Homo sapiens)
        
        2-LTR formation due to circularization of viral DNA (Homo sapiens)

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2-LTR formation due to circularization of viral DNA

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Viral DNA that does not become integrated can undergo another fate, which is to have the two viral DNA ends joined together to form a 2-LTR circle. This reaction requires Ku, XRCC4 and ligase 4.

Literature References

PubMed ID	Title	Journal	Year
16291214	Retroviral DNA integration--mechanism and consequences Bushman, FD, Lewinski, MK	Adv Genet	2005
	Retroviruses Varmus, HE, Hughes, SH, Coffin, JM		1997