All serine residues mentioned above were empirically defined for human IRF3. Multiple sequence alignment of human, mouse and chicken IRF3 by ClustalW showed similarity in the C-terminal domain and the following chicken residues are predicted to be involved in chicken IRF3 activation:
Maniatis, T, Golenbock, DT, McWhirter, SM, Latz, E, Rowe, DC, Liao, SM, Fitzgerald, KA, Faia, KL, Coyle, AJ
McWhirter, SM, Maniatis, T, Harrison, SC, Panne, D
Hiscott, J, Lin, R, Mamane, Y
Hiscott, J, Paz, S, Lin, R, Romieu-Mourez, R, Goubau, D, Nakhaei, P, Sun, Q, Julkunen, I
Nishida, E, Fukuda, M, Suhara, W, Fujita, T, Fukuhara, Y, Yoneyama, M
protein serine/threonine kinase activity of dsRNA:MDA5:IPS1:K63 pUb-TRAF3/or TRAF6:TANK:activated TBK1/or IKK epsilon: IRF3 [mitochondrial outer membrane]
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