TRAF3/or TRAF6 interacts with IPS-1

Stable Identifier
Reaction [binding]
Gallus gallus
Related Species
Infectious bronchitis virus
Locations in the PathwayBrowser
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In mammals, the response to viral infection is mediated through direct and specific interaction between a TRAF-interaction motif (TIM) of IPS-1 and TRAFs, which can recruit other molecules into signaling complex [Ye H et al 2002, Xu LG et al 2005, Saha SK et al 2006, Konno H et al 2009]. IPS-1 harbors few distinct TIMs. One of the motifs is located at aa 143-PVQET-147 and binds both TRAF2 and TRAF3, while TRAF6 exclusively binds to aa 153-PGENSE-158 & 455-PEENEY-460 motifs. IPS-1 mediated response to viral infection in mammals requires:

  • TRAF6 to activate NFkB, MAPK and IRF7, but not IRF3.[Xu LG et al 2005, Yoshida R et al 2009, Konno H et al 2009].
  • TRAF3 to activate IRF3 and IRF7 [Saha SK et al 2006, Oganesyan G et al 2006].
  • TRAF2 to activate p38 MAPK and contribute to NFkB induction [Mikkelsen SS et al 2009, Xu LG et al 2005].

Predicted chicken TRAF2, TRAF3 and TRAF6 proteins show 75, 82 and 73% amino acid sequence identity to their human counterparts respectively. In this project we assume that chicken TRAF proteins function similar to mammalian TRAFs upon viral infection.

Literature References
PubMed ID Title Journal Year
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Takeuchi, O, Kato, A, Goto, H, Tsunetsugu-Yokota, Y, Su, B, Yamazaki, K, Yamamoto, T, Inoue, J, Semba, K, Akira, S, Akiyama, T, Gohda, J, Konno, H, Kawaguchi, Y, Imai, T, Yujiri, T

PLoS One 2009
16153868 VISA is an adapter protein required for virus-triggered IFN-beta signaling

Xu, LG, Shu, HB, Han, KJ, Wang, YY, Zhai, Z, Li, LY

Mol Cell 2005
16858409 Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Pietras, EM, Saha, SK, Oganesyan, G, He, JQ, Wang, Y, Shahangian, A, Kang, JR, Cheng, G, Zarnegar, B, Liu, SY, Shiba, TL

EMBO J 2006
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